TY - JOUR
T1 - Influence of age and comedication on steady-state clonazepam serum level-dose ratios in japanese epileptic patients
AU - Yukawa, E.
AU - Satou, M.
AU - Nonaka, T.
AU - Yukawa, M.
AU - Ohdo, S.
AU - Higuchi, S.
AU - Kuroda, T.
AU - Goto, Y.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - Background: In antiepileptic drugs, the marked inter- and intrapatient variability of the level-dose ratio makes it difficult to predict serum concentrations from the administered per kg dose. It is therefore important to identify factors, such as age and comedication, that could contribute to this observed variability. Objective: To investigate the effect of age and comedication on clonazepam (CZP) level-dose (L/D) ratios. Method: A retrospective evaluation of data from 137 epileptic patients who had received clonazepam. Results: The CZP L/D ratio increased slowly with age up to 15 years in patients on monotherapy. Associated antiepileptic therapy affected the CZP L/D ratio, which was significantly reduced in patients on polytherapy as compared to patients on monotherapy. Conclusion: The study therefore suggests that routine monitoring of CZP serum levels is extremely useful, especially in the paediatric age group, and in patients who require associated antiepileptic medication.
AB - Background: In antiepileptic drugs, the marked inter- and intrapatient variability of the level-dose ratio makes it difficult to predict serum concentrations from the administered per kg dose. It is therefore important to identify factors, such as age and comedication, that could contribute to this observed variability. Objective: To investigate the effect of age and comedication on clonazepam (CZP) level-dose (L/D) ratios. Method: A retrospective evaluation of data from 137 epileptic patients who had received clonazepam. Results: The CZP L/D ratio increased slowly with age up to 15 years in patients on monotherapy. Associated antiepileptic therapy affected the CZP L/D ratio, which was significantly reduced in patients on polytherapy as compared to patients on monotherapy. Conclusion: The study therefore suggests that routine monitoring of CZP serum levels is extremely useful, especially in the paediatric age group, and in patients who require associated antiepileptic medication.
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U2 - 10.1046/j.1365-2710.2001.00372.x
DO - 10.1046/j.1365-2710.2001.00372.x
M3 - Article
C2 - 11679028
AN - SCOPUS:0034782212
SN - 0269-4727
VL - 26
SP - 375
EP - 379
JO - Journal of Clinical Pharmacy and Therapeutics
JF - Journal of Clinical Pharmacy and Therapeutics
IS - 5
ER -