Induction of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of rat brain

Eiji Suzuki; Futoshi Shintani; Shigenobu Kanba; Masahiro Asai; Toshio Nakaki

doi:10.1016/0304-3940(96)12985-2

Induction of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of rat brain

Eiji Suzuki, Futoshi Shintani, Shigenobu Kanba, Masahiro Asai, Toshio Nakaki

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

We investigated whether psychotropics orally administered to rats affect levels of interleukin-1β (IL-1β) and interleukin-1 receptor antagonist (IL-1Ra) mRNA in the hypothalamus, hippocampus, frontal cortex, and brain stem, using a reverse transcription-poymerase chain reaction method. The psychotropics tested were chlorpromazine, haloperidol, imipramine, maprotiline, fluvoxamine, and diazepam. Treatment for 28 days raised the levels of both mRNAs. The increase in IL-1Ra mRNA was 6-112 times larger than that of IL-1β mRNA in most brain regions examined. These results suggest that chronic treatment with psychotropics causes greater amplifying effects on IL-1Ra mRNA than IL-1β mRNA in the brain.

Original language	English
Pages (from-to)	201-204
Number of pages	4
Journal	Neuroscience Letters
Volume	215
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(96)12985-2
Publication status	Published - Sept 13 1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)

Access to Document

10.1016/0304-3940(96)12985-2

Cite this

@article{83180c20d23c4bb48475b84b85d508dc,

title = "Induction of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of rat brain",

abstract = "We investigated whether psychotropics orally administered to rats affect levels of interleukin-1β (IL-1β) and interleukin-1 receptor antagonist (IL-1Ra) mRNA in the hypothalamus, hippocampus, frontal cortex, and brain stem, using a reverse transcription-poymerase chain reaction method. The psychotropics tested were chlorpromazine, haloperidol, imipramine, maprotiline, fluvoxamine, and diazepam. Treatment for 28 days raised the levels of both mRNAs. The increase in IL-1Ra mRNA was 6-112 times larger than that of IL-1β mRNA in most brain regions examined. These results suggest that chronic treatment with psychotropics causes greater amplifying effects on IL-1Ra mRNA than IL-1β mRNA in the brain.",

author = "Eiji Suzuki and Futoshi Shintani and Shigenobu Kanba and Masahiro Asai and Toshio Nakaki",

year = "1996",

month = sep,

day = "13",

doi = "10.1016/0304-3940(96)12985-2",

language = "English",

volume = "215",

pages = "201--204",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Induction of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of rat brain

AU - Suzuki, Eiji

AU - Shintani, Futoshi

AU - Kanba, Shigenobu

AU - Asai, Masahiro

AU - Nakaki, Toshio

PY - 1996/9/13

Y1 - 1996/9/13

N2 - We investigated whether psychotropics orally administered to rats affect levels of interleukin-1β (IL-1β) and interleukin-1 receptor antagonist (IL-1Ra) mRNA in the hypothalamus, hippocampus, frontal cortex, and brain stem, using a reverse transcription-poymerase chain reaction method. The psychotropics tested were chlorpromazine, haloperidol, imipramine, maprotiline, fluvoxamine, and diazepam. Treatment for 28 days raised the levels of both mRNAs. The increase in IL-1Ra mRNA was 6-112 times larger than that of IL-1β mRNA in most brain regions examined. These results suggest that chronic treatment with psychotropics causes greater amplifying effects on IL-1Ra mRNA than IL-1β mRNA in the brain.

AB - We investigated whether psychotropics orally administered to rats affect levels of interleukin-1β (IL-1β) and interleukin-1 receptor antagonist (IL-1Ra) mRNA in the hypothalamus, hippocampus, frontal cortex, and brain stem, using a reverse transcription-poymerase chain reaction method. The psychotropics tested were chlorpromazine, haloperidol, imipramine, maprotiline, fluvoxamine, and diazepam. Treatment for 28 days raised the levels of both mRNAs. The increase in IL-1Ra mRNA was 6-112 times larger than that of IL-1β mRNA in most brain regions examined. These results suggest that chronic treatment with psychotropics causes greater amplifying effects on IL-1Ra mRNA than IL-1β mRNA in the brain.

UR - http://www.scopus.com/inward/record.url?scp=0030582388&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030582388&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(96)12985-2

DO - 10.1016/0304-3940(96)12985-2

M3 - Article

C2 - 8899748

AN - SCOPUS:0030582388

SN - 0304-3940

VL - 215

SP - 201

EP - 204

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Induction of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of rat brain

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this