TY - JOUR
T1 - Induction of bilirubin UDP-glucuronyltransferase and CYP4A1 P450 by co-planar PCBs
T2 - Different responsiveness of guinea pigs and rats
AU - Koga, Y.
AU - Tsuda, M.
AU - Ariyoshi, N.
AU - Ishii, Y.
AU - Yamada, H.
AU - Oguri, K.
AU - Funae, Y.
AU - Yoshimura, H.
N1 - Funding Information:
This study was supported by a grant from the Ministry of Health and Welfare, Japan.
PY - 1994/2
Y1 - 1994/2
N2 - Induction of hepatic microsomal bilirubin UDP_glucuronyltransferase and CYP4A1 P450 by 3,4,3′,4′-tetrachlorobiphenyl (TCB) and 3,4,5,3′,4′-pentachlorobiphenyl (PenCB) was studied in guinea pigs and rats. Both enzyme activities in guinea pigs were increased 4-fold or more over the control by PenCB treatment, while by treatment with a less toxic congener, TCB, these were increased to a lesser extent. On the contrary, the rat enzymes were significantly decreased by treatment with these co-planar polychlorinated biphenyls. These results suggest that the alterations of both bilirubin UDP-glucuronyltransferase and CYP4A P450 are the characteristic indices for the toxicites of polychlorinated hydrocarbons.
AB - Induction of hepatic microsomal bilirubin UDP_glucuronyltransferase and CYP4A1 P450 by 3,4,3′,4′-tetrachlorobiphenyl (TCB) and 3,4,5,3′,4′-pentachlorobiphenyl (PenCB) was studied in guinea pigs and rats. Both enzyme activities in guinea pigs were increased 4-fold or more over the control by PenCB treatment, while by treatment with a less toxic congener, TCB, these were increased to a lesser extent. On the contrary, the rat enzymes were significantly decreased by treatment with these co-planar polychlorinated biphenyls. These results suggest that the alterations of both bilirubin UDP-glucuronyltransferase and CYP4A P450 are the characteristic indices for the toxicites of polychlorinated hydrocarbons.
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U2 - 10.1016/0045-6535(94)90305-0
DO - 10.1016/0045-6535(94)90305-0
M3 - Article
AN - SCOPUS:0028120724
SN - 0045-6535
VL - 28
SP - 639
EP - 645
JO - Chemosphere
JF - Chemosphere
IS - 3
ER -