TY - JOUR
T1 - Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments
AU - Hope, Bruce T.
AU - Nye, Heather E.
AU - Kelz, Max B.
AU - Self, David W.
AU - Iadarola, Michael J.
AU - Nakabeppu, Yusaku
AU - Duman, Ronald S.
AU - Nestler, Eric J.
N1 - Funding Information:
We thank Dr. George S. Robertson, University of Ottawa, Canada for helpful discussions. This work was funded by United States Public Health Service grants DA07359, DA00203, MH45481, and MH25642, and by the Abraham Ribicoff Research Facilities of the Connecticut Mental Health Center, State of Connecticut Department of Mental Health.
PY - 1994/11
Y1 - 1994/11
N2 - Following chronic cocaine treatment, we have found a long-lasting increase in AP-1 binding in the rat nucleus accumbens and striatum, two important targets of the behavioral effects of cocaine. This increase develops gradually over several days and remains at 50% of maximal levels 7 days after the last cocaine exposure. Supershift experiments, along with one- and two-dimensional Western blots, indicate that this chronic AP-1 complex contains at least four Fos-related antigens (FRAs), some of which display ΔFosB-like immunoreactivity, that are induced selectively by chronic, but not acute, cocaine treatment. The same chronic FRAs were also induced by several different types of chronic treatments in a region-specific manner in the brain. Thus, the chronic FBAs and associated chronic AP-1 complex could mediate some of the long-term changes in gene expression unique to the chronic-treated state as opposed to the acute-treated and normal states.
AB - Following chronic cocaine treatment, we have found a long-lasting increase in AP-1 binding in the rat nucleus accumbens and striatum, two important targets of the behavioral effects of cocaine. This increase develops gradually over several days and remains at 50% of maximal levels 7 days after the last cocaine exposure. Supershift experiments, along with one- and two-dimensional Western blots, indicate that this chronic AP-1 complex contains at least four Fos-related antigens (FRAs), some of which display ΔFosB-like immunoreactivity, that are induced selectively by chronic, but not acute, cocaine treatment. The same chronic FRAs were also induced by several different types of chronic treatments in a region-specific manner in the brain. Thus, the chronic FBAs and associated chronic AP-1 complex could mediate some of the long-term changes in gene expression unique to the chronic-treated state as opposed to the acute-treated and normal states.
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U2 - 10.1016/0896-6273(94)90061-2
DO - 10.1016/0896-6273(94)90061-2
M3 - Article
C2 - 7946359
AN - SCOPUS:0027992668
SN - 0896-6273
VL - 13
SP - 1235
EP - 1244
JO - Neuron
JF - Neuron
IS - 5
ER -