TY - JOUR
T1 - Indole-3-carbaldehyde
T2 - A tyrosinase inhibitor from fungus YL185
AU - Shimizu, Kuniyoshi
AU - Geng, Xinglian
AU - Hashiguchi, Mika
AU - Suhara, Hiroto
AU - Fukunaga, Syoko
AU - Yasutake, Seiji
AU - Kondo, Ryuichiro
AU - Tsutsui, Mototake
AU - Sato, Ikuo
PY - 2003
Y1 - 2003
N2 - Indole-3-carbaldehyde (1) was isolated as a tyrosinase inhibitor from the ethyl acetate-soluble fraction of extracellular fluids of unknown fungus YL185. The partial sequencing data of 18S ribosomal DNA (18S rDNA) indicate that this isolate belongs to the family Polyporaceae or Corticiaceae sensu lato. Indole-3-carbaldehyde inhibited the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase with a 50% inhibitory concentration (IC 50) of 1.3 mM and showed inhibitory activity on melanin production in B16 melanoma cells. The aldehyde group of 1 plays an important role in eliciting tyrosinase inhibitory activity.
AB - Indole-3-carbaldehyde (1) was isolated as a tyrosinase inhibitor from the ethyl acetate-soluble fraction of extracellular fluids of unknown fungus YL185. The partial sequencing data of 18S ribosomal DNA (18S rDNA) indicate that this isolate belongs to the family Polyporaceae or Corticiaceae sensu lato. Indole-3-carbaldehyde inhibited the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase with a 50% inhibitory concentration (IC 50) of 1.3 mM and showed inhibitory activity on melanin production in B16 melanoma cells. The aldehyde group of 1 plays an important role in eliciting tyrosinase inhibitory activity.
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U2 - 10.1007/s10086-002-0484-8
DO - 10.1007/s10086-002-0484-8
M3 - Article
AN - SCOPUS:0142103237
SN - 1435-0211
VL - 49
SP - 349
EP - 354
JO - Journal of Wood Science
JF - Journal of Wood Science
IS - 4
ER -