N-type Ca2+ channel α1B-deficient mice have increased activity (ambulation, repetitive behavior, and rearing combined), suggesting contribution by the N-type Ca2+ channel, localized in the plasma membrane and essential for neurotransmitter release, on motor activity. We evaluated the effect of a 6-wk postweaning period of either individual or group housing on the activity displayed in a novel environment with or without previous habituation. Without habituation, male homozygous α1B- deficient mice showed significantly higher activity than wild-type controls, with no influence of the housing condition. When habituated, hyperactivity was seen in individually housed but not group-housed homozygous α 1B-deficient mice. The results indicate that controlling for housing condition can be important when phenotypically analyzing mutant mice.
|Number of pages||4|
|Journal||Journal of the American Association for Laboratory Animal Science|
|Publication status||Published - Sept 2006|
All Science Journal Classification (ASJC) codes
- Animal Science and Zoology