TY - JOUR
T1 - Increased mRNA expression of a novel prostacyclin-stimulating factor in human colon cancer
AU - Umeda, Fumio
AU - Ono, Yasuhiro
AU - Sekiguchi, Naotaka
AU - Hashimoto, Toshihiko
AU - Masakado, Mitsunori
AU - Nakamura, Kazuhiko
AU - Chijiiwa, Yoshiharu
AU - Nawata, Hajime
PY - 1998/4/1
Y1 - 1998/4/1
N2 - We recently cloned a prostacyclin (PGl2)-stimulating factor (PSF), which stimulates PGl2 production by cultured vascular cells. Immunohistochemistry and Northern blot analysis demonstrated that PSF was highly expressed in colon cancer sites compared with normal colon mucosa obtained from the same patient, as well as in cultured adenocarcinoma cell lines compared with cultured normal colon mucosal cell lines. Increased levels of the PSF protein were detected in the culture media of these adenocarcinoma cells compared with levels in the culture media of normal mucosal cells. These results suggest that PSF is closely associated with carcinogenesis of colon mucosa.
AB - We recently cloned a prostacyclin (PGl2)-stimulating factor (PSF), which stimulates PGl2 production by cultured vascular cells. Immunohistochemistry and Northern blot analysis demonstrated that PSF was highly expressed in colon cancer sites compared with normal colon mucosa obtained from the same patient, as well as in cultured adenocarcinoma cell lines compared with cultured normal colon mucosal cell lines. Increased levels of the PSF protein were detected in the culture media of these adenocarcinoma cells compared with levels in the culture media of normal mucosal cells. These results suggest that PSF is closely associated with carcinogenesis of colon mucosa.
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U2 - 10.1007/s005350050072
DO - 10.1007/s005350050072
M3 - Article
C2 - 9605951
AN - SCOPUS:0031915749
SN - 0944-1174
VL - 33
SP - 213
EP - 217
JO - Journal of gastroenterology
JF - Journal of gastroenterology
IS - 2
ER -
