Increased Human Brain Natriuretic Peptide in Congestive Heart Failure

Masashi Mukoyama, Kazuwa Nakao, Yoshihiko Saito, Yoshihiro Ogawa, Kiminori Hosoda, Shin Ichi Suga, Gotaro Shirakami, Michihisa Jougasaki, Hiroo Imura

Research output: Contribution to journalLetterpeer-review

256 Citations (Scopus)


To the Editor: Brain natriuretic peptide (BNP), first isolated from the brains of pigs,1 has a striking similarity to atrial natriuretic peptide (ANP) both in structure and in peripheral and central actions.1 2 3 4 BNP is also a cardiac hormone in pigs5 and rats.6,7 Antiserums against porcine or rat BNP, however, failed to detect BNP-like immunoreactivity in human tissues, indicating the structural diversity of BNP among species. Recently, we isolated human BNP from the atrium and determined its 32-amino-acid sequence.8 We have developed a specific radioimmunoassay for human BNP8 with the use of a monoclonal antibody, modeling it on a radioimmunoassay for.

Original languageEnglish
Pages (from-to)757-758
Number of pages2
JournalNew England Journal of Medicine
Issue number11
Publication statusPublished - Sept 13 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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