TY - JOUR
T1 - Increased expression of the PRL-3 gene in human oral squamous cell carcinoma and dysplasia tissues
AU - Hassan, Nur Mohammad Monsur
AU - Hamada, Jun Ichi
AU - Kameyama, Takeshi
AU - Tada, Mitsuhiro
AU - Nakagawa, Koji
AU - Yoshida, Shoko
AU - Kashiwazaki, Haruhiko
AU - Yamazaki, Yutaka
AU - Suzuki, Yukiko
AU - Sasaki, Akira
AU - Nagatsuka, Hitoshi
AU - Inoue, Nobuo
AU - Moriuchi, Tetsuya
PY - 2011
Y1 - 2011
N2 - Phosphatase of regenerating liver (PRL) belongs to a class of the protein tyrosine phosphatase family, which is known so far to consist of 3 members, PRL-1, PRL-2, and PRL-3. The aim of this study was to uncover the role of PRL genes in development of oral malignancy. We analyzed expression levels of the 3 PRL genes in 50 human oral squamous cell carcinomas (OSCCs), 11 dysplasia and 12 normal mucosa tissues by a real-time RTPCR method. PRL-3 but not PRL-1 or PRL-2 expressions were significantly higher in OSCC and dysplasia than in normal mucosa tissues. Additionally, PRL-3 expressions were significantly higher in OSCC tissues harboring dominant-negative p53 or recessive p53 mutation than in those harboring wild-type p53. These results suggest that PRL-3 plays a role in oral cancer development and can be useful as a marker of pre-malignant and malignant lesion of oral mucosa.
AB - Phosphatase of regenerating liver (PRL) belongs to a class of the protein tyrosine phosphatase family, which is known so far to consist of 3 members, PRL-1, PRL-2, and PRL-3. The aim of this study was to uncover the role of PRL genes in development of oral malignancy. We analyzed expression levels of the 3 PRL genes in 50 human oral squamous cell carcinomas (OSCCs), 11 dysplasia and 12 normal mucosa tissues by a real-time RTPCR method. PRL-3 but not PRL-1 or PRL-2 expressions were significantly higher in OSCC and dysplasia than in normal mucosa tissues. Additionally, PRL-3 expressions were significantly higher in OSCC tissues harboring dominant-negative p53 or recessive p53 mutation than in those harboring wild-type p53. These results suggest that PRL-3 plays a role in oral cancer development and can be useful as a marker of pre-malignant and malignant lesion of oral mucosa.
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M3 - Article
C2 - 21790231
AN - SCOPUS:81255130964
SN - 1513-7368
VL - 12
SP - 947
EP - 951
JO - Asian Pacific Journal of Cancer Prevention
JF - Asian Pacific Journal of Cancer Prevention
IS - 4
ER -
