TY - JOUR
T1 - Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease
AU - Shimura-Miura, Hideki
AU - Hattori, Nobutaka
AU - Kang, Dongchon
AU - Miyako, Ken ichi
AU - Nakabeppu, Yusaku
AU - Mizuno, Yoshikuni
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - There is growing evidence for the involvement of oxidative stress and mitochondrial respiratory failure in nigral neuronal death in Parkinson's disease (PD). We report increased immunoreactivity of 8-oxo-dGTPase (8-oxo-7, 8-dihydrodeoxyguanosine triphosphatase [hMT'H1]), an enzyme known to play an important role in controlling spontaneous mutagenesis, and 8-oxo-7, 8- deoxyguanosine (8-oxo-dG) in the mitochondria of the substantia nigra of 6 PD patients. Our results suggest that hMTH1 might be a rueful marker of oxidative stress and can be used to explore the relation between such oxidative stress and genomic instability.
AB - There is growing evidence for the involvement of oxidative stress and mitochondrial respiratory failure in nigral neuronal death in Parkinson's disease (PD). We report increased immunoreactivity of 8-oxo-dGTPase (8-oxo-7, 8-dihydrodeoxyguanosine triphosphatase [hMT'H1]), an enzyme known to play an important role in controlling spontaneous mutagenesis, and 8-oxo-7, 8- deoxyguanosine (8-oxo-dG) in the mitochondria of the substantia nigra of 6 PD patients. Our results suggest that hMTH1 might be a rueful marker of oxidative stress and can be used to explore the relation between such oxidative stress and genomic instability.
UR - http://www.scopus.com/inward/record.url?scp=0032709404&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032709404&partnerID=8YFLogxK
U2 - 10.1002/1531-8249(199912)46:6<920::AID-ANA17>3.0.CO;2-R
DO - 10.1002/1531-8249(199912)46:6<920::AID-ANA17>3.0.CO;2-R
M3 - Article
C2 - 10589547
AN - SCOPUS:0032709404
SN - 0364-5134
VL - 46
SP - 920
EP - 924
JO - Annals of Neurology
JF - Annals of Neurology
IS - 6
ER -