TY - JOUR
T1 - Incidence of end-stage renal disease and risk factors for progression of renal dysfunction in Japanese patients with type 2 diabetes
T2 - the Fukuoka Diabetes Registry
AU - Iwase, Masanori
AU - Ide, Hitoshi
AU - Ohkuma, Toshiaki
AU - Fujii, Hiroki
AU - Komorita, Yuji
AU - Yoshinari, Masahito
AU - Oku, Yutaro
AU - Higashi, Taiki
AU - Nakamura, Udai
AU - Kitazono, Takanari
N1 - Funding Information:
The authors thank Drs. Dongchon Kang, Shinako Ogata-Kaizu, Yoichiro Hirakawa, Tamaki-Jodai Kitamura, Ai Murao-Kimura, Ayaka Oshiro (Kyushu University), Satoshi Sasaki (The University of Tokyo), Nobuhiro Sasaki (Fukuoka Red Cross Hospital), Kiyohide Nunoi, Yuichi Sato (St. Mary’s Hospital), Daisuke Gotoh (Kyushu Central Hospital), Sakae Nohara (Fukuoka Higashi Medical Center), Yasuhiro Idewaki (Hakujyuji Hospital), Masae Minami (Clinic Minami Masae), Miya Wada (Wada Miya Naika Clinic), Yoshifumi Yokomizo (Yokomizo Naika Clinic), Masanori Kikuchi, Yohei Kikuchi (Kikuchi Naika Clinic), Riku Nomiyama (Suzuki Naika Clinic), Shin Nakamura (Nakamura Naika Clinic), Kenji Tashiro (Oshima Eye Hospital), Mototaka Yoshinari (Yoshinari Naika Clinic), Kojiro Ichikawa (Fukutsu Naika Clinic), Yutaka Kiyohara (Hisayama Research Institute for Lifestyle Diseases). The authors also thank clinical research coordinators Chiho Ohba (Hisayama Research Institute for Lifestyle Diseases), Yoko Nishioka (Kyushu University) as well as those in the administration office: Tomoko Matake (Hisayama Research Institute for Lifestyle Diseases) and Junko Ishimatsu (Kyushu University).
Funding Information:
This work was supported in part by The Japan Society for the Promotion of Science KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology of Japan (grant numbers 23249037 and 23659353 to M.I., 16K00861 to H.F., 19K24229, 21K11700 to T.O., 20K19663 to Y.K.), the Junior Scientist Development Grant supported by the Japan Diabetes Society (to T.O. and Y.K.), a grant from the Japan Diabetes Foundation (to T.O.), Grants for young researchers from Japan Association for Diabetes Education and Care (to T.O.), the Japan Heart Foundation for Research on Atherosclerosis Update (to T.O.), and the Research Grant Program for Bone & Mineral Research (to Y.K.).
Publisher Copyright:
© 2021, Japanese Society of Nephrology.
PY - 2022/2
Y1 - 2022/2
N2 - Background: Epidemiological data regarding diabetic kidney disease are accumulated insufficiently in Japan. We prospectively investigated the incidence of end-stage renal disease (ESRD) and risk factors for progression of renal dysfunction in Japanese patients with type 2 diabetes. Methods: 4904 participants with type 2 diabetes (mean age 65 years, mean estimated glomerular filtration rate (eGFR) 75 mL/min/1.73 m2, proportion of eGFR < 60 mL/min/1.73 m2 21%) were investigated for the progression to ESRD requiring dialysis in multicenter outpatients registry for 5 years. Risk factors for progression of renal dysfunction (≥ 30% decline in eGFR from the baseline and annual eGFR decline rates) were evaluated. Results: The incidence rates of ESRD and all-cause mortality were 4.1/1000 person-years and 12.3/1000 person-years, respectively, and increased according to stages of chronic kidney disease (eGFR < 30 mL/min/1.73 m2, incidence of ESRD 176.6/1000 person-years, all-cause mortality 57.4/1000 person-years). Incidence of ≥ 30% decline in eGFR from the baseline was 16.4% at 5 years, and the mean annual decline rate was −1.84 mL/min/1.73 m2/year. The progression of renal dysfunction was significantly associated with older age, poor glycemic control, blood pressure, albuminuria, eGFR, previous cardiovascular disease, lifestyle factors (body mass index, reduced intake of dietary fiber, increased intake of sodium, no regular exercise), and depressive symptoms. Conclusions: This prospective study has emphasized the importance of multifactorial interventions on risk factors to suppress the high incidence of ESRD in Japanese patients with type 2 diabetes.
AB - Background: Epidemiological data regarding diabetic kidney disease are accumulated insufficiently in Japan. We prospectively investigated the incidence of end-stage renal disease (ESRD) and risk factors for progression of renal dysfunction in Japanese patients with type 2 diabetes. Methods: 4904 participants with type 2 diabetes (mean age 65 years, mean estimated glomerular filtration rate (eGFR) 75 mL/min/1.73 m2, proportion of eGFR < 60 mL/min/1.73 m2 21%) were investigated for the progression to ESRD requiring dialysis in multicenter outpatients registry for 5 years. Risk factors for progression of renal dysfunction (≥ 30% decline in eGFR from the baseline and annual eGFR decline rates) were evaluated. Results: The incidence rates of ESRD and all-cause mortality were 4.1/1000 person-years and 12.3/1000 person-years, respectively, and increased according to stages of chronic kidney disease (eGFR < 30 mL/min/1.73 m2, incidence of ESRD 176.6/1000 person-years, all-cause mortality 57.4/1000 person-years). Incidence of ≥ 30% decline in eGFR from the baseline was 16.4% at 5 years, and the mean annual decline rate was −1.84 mL/min/1.73 m2/year. The progression of renal dysfunction was significantly associated with older age, poor glycemic control, blood pressure, albuminuria, eGFR, previous cardiovascular disease, lifestyle factors (body mass index, reduced intake of dietary fiber, increased intake of sodium, no regular exercise), and depressive symptoms. Conclusions: This prospective study has emphasized the importance of multifactorial interventions on risk factors to suppress the high incidence of ESRD in Japanese patients with type 2 diabetes.
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U2 - 10.1007/s10157-021-02136-2
DO - 10.1007/s10157-021-02136-2
M3 - Article
C2 - 34581896
AN - SCOPUS:85115857186
SN - 1342-1751
VL - 26
SP - 122
EP - 131
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
IS - 2
ER -
