In vivo siRNA delivery with dendritic poly(l-lysine) for the treatment of hypercholesterolemia

Kazuto Watanabe; Mariko Harada-Shiba; Akira Suzuki; Risa Gokuden; Ryohsuke Kurihara; Yusuke Sugao; Takeshi Mori; Yoshiki Katayama; Takuro Niidome

doi:10.1039/b900880b

In vivo siRNA delivery with dendritic poly(l-lysine) for the treatment of hypercholesterolemia

Kazuto Watanabe
, Mariko Harada-Shiba
, Akira Suzuki
, Risa Gokuden
, Ryohsuke Kurihara
, Yusuke Sugao
, Takeshi Mori
, Yoshiki Katayama
, Takuro Niidome

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(l-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.

Original language	English
Pages (from-to)	1306-1310
Number of pages	5
Journal	Molecular BioSystems
Volume	5
Issue number	11
DOIs	https://doi.org/10.1039/b900880b
Publication status	Published - 2009

All Science Journal Classification (ASJC) codes

Biotechnology
Molecular Biology

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10.1039/b900880b

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title = "In vivo siRNA delivery with dendritic poly(l-lysine) for the treatment of hypercholesterolemia",

abstract = "Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(l-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.",

author = "Kazuto Watanabe and Mariko Harada-Shiba and Akira Suzuki and Risa Gokuden and Ryohsuke Kurihara and Yusuke Sugao and Takeshi Mori and Yoshiki Katayama and Takuro Niidome",

year = "2009",

doi = "10.1039/b900880b",

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T1 - In vivo siRNA delivery with dendritic poly(l-lysine) for the treatment of hypercholesterolemia

AU - Watanabe, Kazuto

AU - Harada-Shiba, Mariko

AU - Suzuki, Akira

AU - Gokuden, Risa

AU - Kurihara, Ryohsuke

AU - Sugao, Yusuke

AU - Mori, Takeshi

AU - Katayama, Yoshiki

AU - Niidome, Takuro

PY - 2009

Y1 - 2009

N2 - Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(l-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.

AB - Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(l-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.

UR - https://www.scopus.com/pages/publications/70349976881

UR - https://www.scopus.com/pages/publications/70349976881#tab=citedBy

U2 - 10.1039/b900880b

DO - 10.1039/b900880b

M3 - Article

C2 - 19823746

AN - SCOPUS:70349976881

SN - 1742-206X

VL - 5

SP - 1306

EP - 1310

JO - Molecular BioSystems

JF - Molecular BioSystems

IS - 11

ER -

In vivo siRNA delivery with dendritic poly(l-lysine) for the treatment of hypercholesterolemia

Abstract

All Science Journal Classification (ASJC) codes

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