In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent

Tatsuhiro Yamamoto; Kenjiro Ikuta; Keiji Oi; Kohtaro Abe; Toyokazu Uwatoku; Fuminori Hyodo; Masaharu Murata; Noboru Shigetani; Kengo Yoshimitsu; Hiroaki Shimokawa; Hideo Utsumi; Yoshiki Katayama

doi:10.1016/j.bmcl.2004.03.066

In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent

Tatsuhiro Yamamoto, Kenjiro Ikuta, Keiji Oi, Kohtaro Abe, Toyokazu Uwatoku, Fuminori Hyodo, Masaharu Murata, Noboru Shigetani, Kengo Yoshimitsu, Hiroaki Shimokawa, Hideo Utsumi, Yoshiki Katayama

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.

Original language	English
Pages (from-to)	2787-2790
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2004.03.066
Publication status	Published - Jun 7 2004

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2004.03.066

Cite this

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title = "In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent",

abstract = "A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.",

author = "Tatsuhiro Yamamoto and Kenjiro Ikuta and Keiji Oi and Kohtaro Abe and Toyokazu Uwatoku and Fuminori Hyodo and Masaharu Murata and Noboru Shigetani and Kengo Yoshimitsu and Hiroaki Shimokawa and Hideo Utsumi and Yoshiki Katayama",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and also from the Ministry of Health, Labour, and Welfare of Japan.",

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doi = "10.1016/j.bmcl.2004.03.066",

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T1 - In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent

AU - Yamamoto, Tatsuhiro

AU - Ikuta, Kenjiro

AU - Oi, Keiji

AU - Abe, Kohtaro

AU - Uwatoku, Toyokazu

AU - Hyodo, Fuminori

AU - Murata, Masaharu

AU - Shigetani, Noboru

AU - Yoshimitsu, Kengo

AU - Shimokawa, Hiroaki

AU - Utsumi, Hideo

AU - Katayama, Yoshiki

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and also from the Ministry of Health, Labour, and Welfare of Japan.

PY - 2004/6/7

Y1 - 2004/6/7

N2 - A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.

AB - A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.

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In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent

Abstract

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