In vivo diagnosis and therapy of human tumors with monoclonal antibodies: Selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung

James L. Mulshine; Ingalil Avis; Anthony M. Treston; Philip G. Kasprzyk; Yoichi Nakanishi; Cindy Mobley; Jorge A. Carrasquillo; Steven M. Larson; Bruce Merchant; Frank Cuttitta

doi:10.1016/0883-2897(89)90189-X

In vivo diagnosis and therapy of human tumors with monoclonal antibodies: Selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung

James L. Mulshine, Ingalil Avis, Anthony M. Treston, Philip G. Kasprzyk, Yoichi Nakanishi, Cindy Mobley, Jorge A. Carrasquillo, Steven M. Larson, Bruce Merchant, Frank Cuttitta

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Initial monoclonal antibody therapy trials include an attempt to control malignant proliferation of small cell lung cancer by blocking the autocrine stimulation of gastrin releasing peptide. A critical issue is the adequacy of antibody penetration into the tumor bed to effect immunologic blockade of the mitogenic peptide. The use of an indium-111 antibody chelate which is coadministered with the first therapeutic antibody administration facilitates analysis of the pharmacokinetic dynamics for this trial. If this approach is successful with gastrin releasing peptide, other peptide hormones with autocrine effects could also be targeted. A combination of anti growth factor therapies could lead to successful therapeutic control of this lethal disease.

Original language	English
Pages (from-to)	159-162
Number of pages	4
Journal	International Journal of Radiation Applications and Instrumentation.
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/0883-2897(89)90189-X
Publication status	Published - 1989
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0883-2897(89)90189-X

Cite this

Mulshine, J. L., Avis, I., Treston, A. M., Kasprzyk, P. G., Nakanishi, Y., Mobley, C., Carrasquillo, J. A., Larson, S. M., Merchant, B., & Cuttitta, F. (1989). In vivo diagnosis and therapy of human tumors with monoclonal antibodies: Selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung. International Journal of Radiation Applications and Instrumentation., 16(2), 159-162. https://doi.org/10.1016/0883-2897(89)90189-X

In vivo diagnosis and therapy of human tumors with monoclonal antibodies: Selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung. / Mulshine, James L.; Avis, Ingalil; Treston, Anthony M. et al.
In: International Journal of Radiation Applications and Instrumentation., Vol. 16, No. 2, 1989, p. 159-162.

Research output: Contribution to journal › Article › peer-review

Mulshine, JL, Avis, I, Treston, AM, Kasprzyk, PG, Nakanishi, Y, Mobley, C, Carrasquillo, JA, Larson, SM, Merchant, B & Cuttitta, F 1989, 'In vivo diagnosis and therapy of human tumors with monoclonal antibodies: Selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung', International Journal of Radiation Applications and Instrumentation., vol. 16, no. 2, pp. 159-162. https://doi.org/10.1016/0883-2897(89)90189-X

@article{45e3c5273d2f473b85e6bf6068e9a0f3,

title = "In vivo diagnosis and therapy of human tumors with monoclonal antibodies: Selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung",

abstract = "Initial monoclonal antibody therapy trials include an attempt to control malignant proliferation of small cell lung cancer by blocking the autocrine stimulation of gastrin releasing peptide. A critical issue is the adequacy of antibody penetration into the tumor bed to effect immunologic blockade of the mitogenic peptide. The use of an indium-111 antibody chelate which is coadministered with the first therapeutic antibody administration facilitates analysis of the pharmacokinetic dynamics for this trial. If this approach is successful with gastrin releasing peptide, other peptide hormones with autocrine effects could also be targeted. A combination of anti growth factor therapies could lead to successful therapeutic control of this lethal disease.",

author = "Mulshine, {James L.} and Ingalil Avis and Treston, {Anthony M.} and Kasprzyk, {Philip G.} and Yoichi Nakanishi and Cindy Mobley and Carrasquillo, {Jorge A.} and Larson, {Steven M.} and Bruce Merchant and Frank Cuttitta",

note = "Funding Information: {\textquoteleft}National Cancer Institute, Navy Medical Oncology Branch Clinical Oncology Program, Division of Cancer Treatment, National Cancer Institute and National Institutes of Health, Naval Hospital, Bethesda, MD 20814, U.S.A., *Nuclear Medicine, Clinical Center, National Institutes of Health, Bethesda, MC 20892, U.S.A. and {\textquoteleft}Hybritech, Inc., San Diego, Calif., U.S.A.",

year = "1989",

doi = "10.1016/0883-2897(89)90189-X",

language = "English",

volume = "16",

pages = "159--162",

journal = "International Journal of Radiation Applications and Instrumentation.",

issn = "0883-2897",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - In vivo diagnosis and therapy of human tumors with monoclonal antibodies

T2 - Selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung

AU - Mulshine, James L.

AU - Avis, Ingalil

AU - Treston, Anthony M.

AU - Kasprzyk, Philip G.

AU - Nakanishi, Yoichi

AU - Mobley, Cindy

AU - Carrasquillo, Jorge A.

AU - Larson, Steven M.

AU - Merchant, Bruce

AU - Cuttitta, Frank

N1 - Funding Information: ‘National Cancer Institute, Navy Medical Oncology Branch Clinical Oncology Program, Division of Cancer Treatment, National Cancer Institute and National Institutes of Health, Naval Hospital, Bethesda, MD 20814, U.S.A., *Nuclear Medicine, Clinical Center, National Institutes of Health, Bethesda, MC 20892, U.S.A. and ‘Hybritech, Inc., San Diego, Calif., U.S.A.

PY - 1989

Y1 - 1989

N2 - Initial monoclonal antibody therapy trials include an attempt to control malignant proliferation of small cell lung cancer by blocking the autocrine stimulation of gastrin releasing peptide. A critical issue is the adequacy of antibody penetration into the tumor bed to effect immunologic blockade of the mitogenic peptide. The use of an indium-111 antibody chelate which is coadministered with the first therapeutic antibody administration facilitates analysis of the pharmacokinetic dynamics for this trial. If this approach is successful with gastrin releasing peptide, other peptide hormones with autocrine effects could also be targeted. A combination of anti growth factor therapies could lead to successful therapeutic control of this lethal disease.

AB - Initial monoclonal antibody therapy trials include an attempt to control malignant proliferation of small cell lung cancer by blocking the autocrine stimulation of gastrin releasing peptide. A critical issue is the adequacy of antibody penetration into the tumor bed to effect immunologic blockade of the mitogenic peptide. The use of an indium-111 antibody chelate which is coadministered with the first therapeutic antibody administration facilitates analysis of the pharmacokinetic dynamics for this trial. If this approach is successful with gastrin releasing peptide, other peptide hormones with autocrine effects could also be targeted. A combination of anti growth factor therapies could lead to successful therapeutic control of this lethal disease.

UR - http://www.scopus.com/inward/record.url?scp=45349111055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=45349111055&partnerID=8YFLogxK

U2 - 10.1016/0883-2897(89)90189-X

DO - 10.1016/0883-2897(89)90189-X

M3 - Article

C2 - 2541112

AN - SCOPUS:45349111055

SN - 0883-2897

VL - 16

SP - 159

EP - 162

JO - International Journal of Radiation Applications and Instrumentation.

JF - International Journal of Radiation Applications and Instrumentation.

IS - 2

ER -

In vivo diagnosis and therapy of human tumors with monoclonal antibodies: Selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this