TY - JOUR
T1 - In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-d-aspartate receptor blockers
AU - Nakamura, Motoomi
AU - Abe, Shimako
AU - Goto, Yoshinobu
AU - Chishaki, Akiko
AU - Akazawa, Kouhei
AU - Kato, Motohiro
N1 - Funding Information:
The authors are grateful to Dr. T. Yamamoto for advice on white-noise generation, Dr. Y. Nose for helpful discussions, and Dr. N.S. Peachey for critically reviewing the manuscript. This study was supported in part by grants from the Salt Science Research Foundation (9 131 , 92045) the Ministry of Health and Welfare, and from the Ministry of Education, Science and Culture (No. 04454273). Japan.
PY - 1994/3
Y1 - 1994/3
N2 - The behavioral changes associated with seizures induced by auditory stimulation in magnesium (Mg)-deficient rats originate in deep brain structures and secondarily project to neocortex. In the present study, we examined the roles of N-methyl-d-aspartate (NMDA) receptors in this seizure model. The intraperitoneal administration of the competitive NMDA receptor blocker dl-2-amino-7-phosphonoheptanoic acid (36 and 72 mg/kg) and the non-competitive NMDA receptor blocker MK-801 (1.35 and 2.7 mg/kg), completely prevented the induction of seizure and bradyarrhythmia or sudden death resulting from seizure. Therefore, the white-noise-induced seizures in Mg-deficient rats are linked to increased neuronal excitability via the NMDA receptor.
AB - The behavioral changes associated with seizures induced by auditory stimulation in magnesium (Mg)-deficient rats originate in deep brain structures and secondarily project to neocortex. In the present study, we examined the roles of N-methyl-d-aspartate (NMDA) receptors in this seizure model. The intraperitoneal administration of the competitive NMDA receptor blocker dl-2-amino-7-phosphonoheptanoic acid (36 and 72 mg/kg) and the non-competitive NMDA receptor blocker MK-801 (1.35 and 2.7 mg/kg), completely prevented the induction of seizure and bradyarrhythmia or sudden death resulting from seizure. Therefore, the white-noise-induced seizures in Mg-deficient rats are linked to increased neuronal excitability via the NMDA receptor.
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U2 - 10.1016/0920-1211(94)90055-8
DO - 10.1016/0920-1211(94)90055-8
M3 - Article
C2 - 8013447
AN - SCOPUS:0028348984
SN - 0920-1211
VL - 17
SP - 249
EP - 256
JO - Epilepsy Research
JF - Epilepsy Research
IS - 3
ER -