In vitro screening of angiotensin I-converting enzyme inhibitory activities in traditional plant medicines of Indonesia and Peru

Yuji Tsutsumi; Nozomi Fujii; Tomoaki Nishida; Ryo Soda; Ko Ichi Oshiman

In vitro screening of angiotensin I-converting enzyme inhibitory activities in traditional plant medicines of Indonesia and Peru

Yuji Tsutsumi
, Nozomi Fujii
, Tomoaki Nishida
, Ryo Soda
, Ko Ichi Oshiman

Research output: Contribution to journal › Article › peer-review

Abstract

A total of 110 extracts from 83 Indonesian traditional plant medicines and from 11 samples from Peru were subjected to the screening of angiotensin 1-converting enzyme (ACE) inhibitors by the in vitro ACE inhibitory assay at a fixed concentration, and the IC₅₀ values for the selected 17 extracts were determined. The 100% ethanol extract from Majakani (Quercus lusitanica) showed the highest inhibitory activity and its IC₅₀ was 5.7 μg/ml.

Original language	English
Pages (from-to)	7-13
Number of pages	7
Journal	Natural Medicines
Volume	54
Issue number	1
Publication status	Published - Feb 2000
Externally published	Yes

All Science Journal Classification (ASJC) codes

Drug Discovery
Complementary and alternative medicine
Pharmaceutical Science
Organic Chemistry

Cite this

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title = "In vitro screening of angiotensin I-converting enzyme inhibitory activities in traditional plant medicines of Indonesia and Peru",

abstract = "A total of 110 extracts from 83 Indonesian traditional plant medicines and from 11 samples from Peru were subjected to the screening of angiotensin 1-converting enzyme (ACE) inhibitors by the in vitro ACE inhibitory assay at a fixed concentration, and the IC50 values for the selected 17 extracts were determined. The 100\% ethanol extract from Majakani (Quercus lusitanica) showed the highest inhibitory activity and its IC50 was 5.7 μg/ml.",

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AU - Tsutsumi, Yuji

AU - Fujii, Nozomi

AU - Nishida, Tomoaki

AU - Soda, Ryo

AU - Oshiman, Ko Ichi

PY - 2000/2

Y1 - 2000/2

N2 - A total of 110 extracts from 83 Indonesian traditional plant medicines and from 11 samples from Peru were subjected to the screening of angiotensin 1-converting enzyme (ACE) inhibitors by the in vitro ACE inhibitory assay at a fixed concentration, and the IC50 values for the selected 17 extracts were determined. The 100% ethanol extract from Majakani (Quercus lusitanica) showed the highest inhibitory activity and its IC50 was 5.7 μg/ml.

AB - A total of 110 extracts from 83 Indonesian traditional plant medicines and from 11 samples from Peru were subjected to the screening of angiotensin 1-converting enzyme (ACE) inhibitors by the in vitro ACE inhibitory assay at a fixed concentration, and the IC50 values for the selected 17 extracts were determined. The 100% ethanol extract from Majakani (Quercus lusitanica) showed the highest inhibitory activity and its IC50 was 5.7 μg/ml.

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M3 - Article

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In vitro screening of angiotensin I-converting enzyme inhibitory activities in traditional plant medicines of Indonesia and Peru

Abstract

All Science Journal Classification (ASJC) codes

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