In vitro chemosensitivity test: succinate dehydrogenase inhibition (SDI) test

Y. Maehara, S. Kohnoe, Y. Emi, Y. Sakaguchi, K. Sugimachi

Research output: Contribution to journalArticlepeer-review


The succinate dehydrogenase inhibition (SDI) test was used for determining chemosensitivity of various human tumors. This test was based on the correlation between the cellular succinate dehydrogenase activity as determined by 3-(4,5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H tetrazolium bromide (MTT), and cell viability. The chemosensitivity varied in the tissue. Some factors are involved in the chemosensitivity, that is origin of a tumor, tissue differentiation and tissue DNA synthetic activity. This test is a convenient method for clinical use and provides important information about chemosensitivity.

Original languageEnglish
Pages (from-to)14-18
Number of pages5
JournalRinsho byori. The Japanese journal of clinical pathology
Issue number1
Publication statusPublished - Jan 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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