In vitro biodegradability of chitosan-organosiloxane hybrid membrane

K. Tsuru, Y. Shirosaki, S. Hayakawa, A. Osaka, M. A. Lopes, J. D. Santos, M. H. Fernandas

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Chitosan-silicate hybrid membranes were prepared using γ- glycidoxypropyltrimethoxysilane (GPSM) through a sol-gel process. The amino groups of chitosan chains were reacted with the epoxy groups of GPSM and GPSM have a function as the agent to cross-link the chitosan chains. The cross-linking degree of the hybrid membranes was determined by ninhydrin assay. Fourier-transform infrared (FT-IR) spectroscopy and 29Si cross-polarization (CP) magic-angle spinning (MAS)-NMR spectroscopy were used to assess the structure of the hybrid membranes. The biodegradability of the hybrid membranes in phosphate-buffered saline solution or lysozyme solution was investigated as a function of the GPSM concentration.

Original languageEnglish
Pages (from-to)823-826
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering


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