TY - JOUR
T1 - Importance of interaction between C1 domain and lipids in protein kinase Cα activation
T2 - Hydrophobic side chain direction in isobenzofuranone ligands controls enzyme activation level
AU - Hirai, Go
AU - Shimizu, Adashi
AU - Watanabe, Toru
AU - Ogoshi, Yosuke
AU - Ohkubo, Megumi
AU - Sodeoka, Mikiko
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/7/9
Y1 - 2007/7/9
N2 - Substituent direction is important: Type A-D isobenzofuranone derivatives were synthesized with differently directed hydrophobic alkyl side chains. These ligands bind in a similar conformation to protein kinase Cα but have contrasting activation abilities, possibly owing to different interaction of the side chain with the membrane lipid. (Chemical Equation Presented)
AB - Substituent direction is important: Type A-D isobenzofuranone derivatives were synthesized with differently directed hydrophobic alkyl side chains. These ligands bind in a similar conformation to protein kinase Cα but have contrasting activation abilities, possibly owing to different interaction of the side chain with the membrane lipid. (Chemical Equation Presented)
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U2 - 10.1002/cmdc.200700080
DO - 10.1002/cmdc.200700080
M3 - Article
C2 - 17492704
AN - SCOPUS:49649129954
SN - 1860-7179
VL - 2
SP - 1006
EP - 1009
JO - ChemMedChem
JF - ChemMedChem
IS - 7
ER -