Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer

Yoshifumi Iwagami; Hidetoshi Eguchi; Hiroshi Wada; Yoshito Tomimaru; Naoki Hama; Koichi Kawamoto; Shogo Kobayashi; Masaki Mori; Yuichiro Doki; Hiroaki Nagano

doi:10.1007/s00595-014-0964-7

Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer

Yoshifumi Iwagami, Hidetoshi Eguchi, Hiroshi Wada, Yoshito Tomimaru, Naoki Hama, Koichi Kawamoto, Shogo Kobayashi, Masaki Mori, Yuichiro Doki, Hiroaki Nagano

Surgery

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Purpose: The aim of this study was to determine the utility of the peritoneal lavage cytology findings in predicting the clinical outcomes of resectable left-sided pancreatic cancer.

Results: Five patients (12.8 %) had malignant cells in the cytology samples (positive cytology). This occurred more frequently in patients with vascular invasion (P = 0.008). Positive cytology was significantly associated with lower overall (P = 0.0007) and recurrent-free (P < 0.0001) survival rates. Positive cytology was an independent prognostic factor for recurrence (P = 0.022); it was closely associated with local recurrence, peritoneal recurrence and distant metastasis.

Methods: Peritoneal lavage samples were collected from 39 consecutive patients who underwent surgery for left-sided pancreatic cancer between January 2000 and December 2010. We analyzed the correlations between the peritoneal lavage cytology findings and the clinical outcomes.

Conclusion: Surgeons should carefully consider the intraoperative diagnosis of peritoneal lavage cytology in patients with resectable left-sided pancreatic cancers, because patients with positive cytology are likely to experience recurrence.

Original language	English
Pages (from-to)	444-450
Number of pages	7
Journal	Surgery today
Volume	45
Issue number	4
DOIs	https://doi.org/10.1007/s00595-014-0964-7
Publication status	Published - Apr 2015

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Surgery

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10.1007/s00595-014-0964-7

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title = "Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer",

abstract = "Purpose: The aim of this study was to determine the utility of the peritoneal lavage cytology findings in predicting the clinical outcomes of resectable left-sided pancreatic cancer.Results: Five patients (12.8 %) had malignant cells in the cytology samples (positive cytology). This occurred more frequently in patients with vascular invasion (P = 0.008). Positive cytology was significantly associated with lower overall (P = 0.0007) and recurrent-free (P < 0.0001) survival rates. Positive cytology was an independent prognostic factor for recurrence (P = 0.022); it was closely associated with local recurrence, peritoneal recurrence and distant metastasis.Methods: Peritoneal lavage samples were collected from 39 consecutive patients who underwent surgery for left-sided pancreatic cancer between January 2000 and December 2010. We analyzed the correlations between the peritoneal lavage cytology findings and the clinical outcomes.Conclusion: Surgeons should carefully consider the intraoperative diagnosis of peritoneal lavage cytology in patients with resectable left-sided pancreatic cancers, because patients with positive cytology are likely to experience recurrence.",

author = "Yoshifumi Iwagami and Hidetoshi Eguchi and Hiroshi Wada and Yoshito Tomimaru and Naoki Hama and Koichi Kawamoto and Shogo Kobayashi and Masaki Mori and Yuichiro Doki and Hiroaki Nagano",

note = "Publisher Copyright: {\textcopyright} 2014, Springer Japan.",

year = "2015",

month = apr,

doi = "10.1007/s00595-014-0964-7",

language = "English",

volume = "45",

pages = "444--450",

journal = "Surgery today",

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TY - JOUR

T1 - Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer

AU - Iwagami, Yoshifumi

AU - Eguchi, Hidetoshi

AU - Wada, Hiroshi

AU - Tomimaru, Yoshito

AU - Hama, Naoki

AU - Kawamoto, Koichi

AU - Kobayashi, Shogo

AU - Mori, Masaki

AU - Doki, Yuichiro

AU - Nagano, Hiroaki

PY - 2015/4

Y1 - 2015/4

N2 - Purpose: The aim of this study was to determine the utility of the peritoneal lavage cytology findings in predicting the clinical outcomes of resectable left-sided pancreatic cancer.Results: Five patients (12.8 %) had malignant cells in the cytology samples (positive cytology). This occurred more frequently in patients with vascular invasion (P = 0.008). Positive cytology was significantly associated with lower overall (P = 0.0007) and recurrent-free (P < 0.0001) survival rates. Positive cytology was an independent prognostic factor for recurrence (P = 0.022); it was closely associated with local recurrence, peritoneal recurrence and distant metastasis.Methods: Peritoneal lavage samples were collected from 39 consecutive patients who underwent surgery for left-sided pancreatic cancer between January 2000 and December 2010. We analyzed the correlations between the peritoneal lavage cytology findings and the clinical outcomes.Conclusion: Surgeons should carefully consider the intraoperative diagnosis of peritoneal lavage cytology in patients with resectable left-sided pancreatic cancers, because patients with positive cytology are likely to experience recurrence.

AB - Purpose: The aim of this study was to determine the utility of the peritoneal lavage cytology findings in predicting the clinical outcomes of resectable left-sided pancreatic cancer.Results: Five patients (12.8 %) had malignant cells in the cytology samples (positive cytology). This occurred more frequently in patients with vascular invasion (P = 0.008). Positive cytology was significantly associated with lower overall (P = 0.0007) and recurrent-free (P < 0.0001) survival rates. Positive cytology was an independent prognostic factor for recurrence (P = 0.022); it was closely associated with local recurrence, peritoneal recurrence and distant metastasis.Methods: Peritoneal lavage samples were collected from 39 consecutive patients who underwent surgery for left-sided pancreatic cancer between January 2000 and December 2010. We analyzed the correlations between the peritoneal lavage cytology findings and the clinical outcomes.Conclusion: Surgeons should carefully consider the intraoperative diagnosis of peritoneal lavage cytology in patients with resectable left-sided pancreatic cancers, because patients with positive cytology are likely to experience recurrence.

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JO - Surgery today

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Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer

Abstract

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