TY - JOUR
T1 - Implications of IL-13Rα2 in atopic skin inflammation
AU - Furue, Masutaka
AU - Ulzii, Dugarmaa
AU - Nakahara, Takeshi
AU - Tsuji, Gaku
AU - Furue, Kazuhisa
AU - Hashimoto-Hachiya, Akiko
AU - Kido-Nakahara, Makiko
N1 - Funding Information:
This work was partly supported by grants from The Ministry of Health, Labour and Welfare, Japan ( H30-Shokuhin-Shitei-005 ) and The Leading Advanced Projects for Medical Innovation, Japan (LEAP) .
Publisher Copyright:
© 2020 Japanese Society of Allergology
PY - 2020/7
Y1 - 2020/7
N2 - Atopic dermatitis (AD) is a common eczematous skin disorder characterized by skin inflammation, barrier disruption, chronic pruritus and marked scratching. Th2 cytokines, especially IL-13, play a pathogenic role in AD. IL-13 signals via a heterodimeric receptor composed of IL-4Rα and IL-13 Rα1. A second receptor, IL-13 Rα2, binds to IL-13 with high affinity, but it works as a decoy receptor. IL-13 Rα2 is overexpressed in the lesional skin of AD. Notably, mechanical scratching, as well as IL-13 itself, also upregulates IL-13 Rα2 expression. The scratch-induced IL-13 Rα2 upregulation may attenuate the IL-13-mediated epidermal barrier dysfunction and dermal fibrosis. Recent studies stress an importance of another IL-13 Rα2 ligand, chitinase 3-like 1 or YKL-40 in Th2 differentiation. However, the implications of increased IL-13 Rα2 levels remain elusive in AD. In this review, we summarize the recent topics on IL-13 Rα2 in atopic skin inflammation.
AB - Atopic dermatitis (AD) is a common eczematous skin disorder characterized by skin inflammation, barrier disruption, chronic pruritus and marked scratching. Th2 cytokines, especially IL-13, play a pathogenic role in AD. IL-13 signals via a heterodimeric receptor composed of IL-4Rα and IL-13 Rα1. A second receptor, IL-13 Rα2, binds to IL-13 with high affinity, but it works as a decoy receptor. IL-13 Rα2 is overexpressed in the lesional skin of AD. Notably, mechanical scratching, as well as IL-13 itself, also upregulates IL-13 Rα2 expression. The scratch-induced IL-13 Rα2 upregulation may attenuate the IL-13-mediated epidermal barrier dysfunction and dermal fibrosis. Recent studies stress an importance of another IL-13 Rα2 ligand, chitinase 3-like 1 or YKL-40 in Th2 differentiation. However, the implications of increased IL-13 Rα2 levels remain elusive in AD. In this review, we summarize the recent topics on IL-13 Rα2 in atopic skin inflammation.
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U2 - 10.1016/j.alit.2020.01.005
DO - 10.1016/j.alit.2020.01.005
M3 - Review article
C2 - 32037147
AN - SCOPUS:85079017342
SN - 1323-8930
VL - 69
SP - 412
EP - 416
JO - Allergology International
JF - Allergology International
IS - 3
ER -