Implantable CMOS image sensor with a neural amplifier for simultaneous recording of optical and electrophysiological signals

Kenji Sugie; Kiyotaka Sasagawa; Yasumi Ohta; Hironari Takehara; Makito Haruta; Hiroyuki Tashiro; Jun Ohta

doi:10.1109/BioCAS49922.2021.9644940

Implantable CMOS image sensor with a neural amplifier for simultaneous recording of optical and electrophysiological signals

Kenji Sugie, Kiyotaka Sasagawa, Yasumi Ohta, Hironari Takehara, Makito Haruta, Hiroyuki Tashiro, Jun Ohta

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Citations (Scopus)

Abstract

In this work, we developed an implantable device for simultaneous optical observation and electrophysiological recording. The prototype image sensor was designed using a 0.35-m standard complementary metal-oxide-semiconductor process, and green fluorescent protein fluorescence imaging of mouse brain slices was performed using the image sensor. In addition, a neural amplifier integrated on the same chip to amplify the weak neural signals obtained a midband gain of 39 dB at 40 mHz-3 kHz, and the input-referred noise was 4.9 Vrms. Crosstalk of the image sensor clock signal observed in the neural amplifier output was reduced using a software filter.

Original language	English
Title of host publication	BioCAS 2021 - IEEE Biomedical Circuits and Systems Conference, Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781728172040
DOIs	https://doi.org/10.1109/BioCAS49922.2021.9644940
Publication status	Published - 2021
Externally published	Yes
Event	2021 IEEE Biomedical Circuits and Systems Conference, BioCAS 2021 - Virtual, Online, Germany Duration: Oct 6 2021 → Oct 9 2021

Publication series

Name	BioCAS 2021 - IEEE Biomedical Circuits and Systems Conference, Proceedings

Conference

Conference	2021 IEEE Biomedical Circuits and Systems Conference, BioCAS 2021
Country/Territory	Germany
City	Virtual, Online
Period	10/6/21 → 10/9/21

All Science Journal Classification (ASJC) codes

Hardware and Architecture
Biomedical Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/BioCAS49922.2021.9644940

Cite this

Sugie, K., Sasagawa, K., Ohta, Y., Takehara, H., Haruta, M., Tashiro, H., & Ohta, J. (2021). Implantable CMOS image sensor with a neural amplifier for simultaneous recording of optical and electrophysiological signals. In BioCAS 2021 - IEEE Biomedical Circuits and Systems Conference, Proceedings (BioCAS 2021 - IEEE Biomedical Circuits and Systems Conference, Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BioCAS49922.2021.9644940

Implantable CMOS image sensor with a neural amplifier for simultaneous recording of optical and electrophysiological signals. / Sugie, Kenji; Sasagawa, Kiyotaka; Ohta, Yasumi et al.
BioCAS 2021 - IEEE Biomedical Circuits and Systems Conference, Proceedings. Institute of Electrical and Electronics Engineers Inc., 2021. (BioCAS 2021 - IEEE Biomedical Circuits and Systems Conference, Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sugie, K, Sasagawa, K, Ohta, Y, Takehara, H, Haruta, M, Tashiro, H & Ohta, J 2021, Implantable CMOS image sensor with a neural amplifier for simultaneous recording of optical and electrophysiological signals. in BioCAS 2021 - IEEE Biomedical Circuits and Systems Conference, Proceedings. BioCAS 2021 - IEEE Biomedical Circuits and Systems Conference, Proceedings, Institute of Electrical and Electronics Engineers Inc., 2021 IEEE Biomedical Circuits and Systems Conference, BioCAS 2021, Virtual, Online, Germany, 10/6/21. https://doi.org/10.1109/BioCAS49922.2021.9644940

Sugie K, Sasagawa K, Ohta Y, Takehara H, Haruta M, Tashiro H et al. Implantable CMOS image sensor with a neural amplifier for simultaneous recording of optical and electrophysiological signals. In BioCAS 2021 - IEEE Biomedical Circuits and Systems Conference, Proceedings. Institute of Electrical and Electronics Engineers Inc. 2021. (BioCAS 2021 - IEEE Biomedical Circuits and Systems Conference, Proceedings). doi: 10.1109/BioCAS49922.2021.9644940

Sugie, Kenji ; Sasagawa, Kiyotaka ; Ohta, Yasumi et al. / Implantable CMOS image sensor with a neural amplifier for simultaneous recording of optical and electrophysiological signals. BioCAS 2021 - IEEE Biomedical Circuits and Systems Conference, Proceedings. Institute of Electrical and Electronics Engineers Inc., 2021. (BioCAS 2021 - IEEE Biomedical Circuits and Systems Conference, Proceedings).

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abstract = "In this work, we developed an implantable device for simultaneous optical observation and electrophysiological recording. The prototype image sensor was designed using a 0.35-m standard complementary metal-oxide-semiconductor process, and green fluorescent protein fluorescence imaging of mouse brain slices was performed using the image sensor. In addition, a neural amplifier integrated on the same chip to amplify the weak neural signals obtained a midband gain of 39 dB at 40 mHz-3 kHz, and the input-referred noise was 4.9 Vrms. Crosstalk of the image sensor clock signal observed in the neural amplifier output was reduced using a software filter.",

author = "Kenji Sugie and Kiyotaka Sasagawa and Yasumi Ohta and Hironari Takehara and Makito Haruta and Hiroyuki Tashiro and Jun Ohta",

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AB - In this work, we developed an implantable device for simultaneous optical observation and electrophysiological recording. The prototype image sensor was designed using a 0.35-m standard complementary metal-oxide-semiconductor process, and green fluorescent protein fluorescence imaging of mouse brain slices was performed using the image sensor. In addition, a neural amplifier integrated on the same chip to amplify the weak neural signals obtained a midband gain of 39 dB at 40 mHz-3 kHz, and the input-referred noise was 4.9 Vrms. Crosstalk of the image sensor clock signal observed in the neural amplifier output was reduced using a software filter.

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Implantable CMOS image sensor with a neural amplifier for simultaneous recording of optical and electrophysiological signals

Abstract

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All Science Journal Classification (ASJC) codes

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