TY - JOUR
T1 - Impact of surface functionalization with phosphate and calcium on the biological performance of Ti-6Al-4V
AU - Sunarso,
AU - Tsuchiya, Akira
AU - Toita, Riki
AU - Tsuru, Kanji
AU - Ishikawa, Kunio
N1 - Funding Information:
This work was supported by AMED [No. JP21im0502004 ], JSPS KAKENHI [No. JP18K12091 ].
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - This study aimed to determine the bioactivities and osseointegration activities of Ti-6Al-4V after surface functionalization with a combination of phosphate and calcium. Several Ti-6Al-4V containing different amounts of phosphate and/or calcium on their surface were prepared. Phosphate was introduced by allowing samples to react with H3PO4, and the resulting phosphate-modified samples were further allowed to react with CaCl2 to obtain phosphate- and calcium-co-immobilized samples. Cell studies revealed that the co-immobilization of phosphate and calcium significantly promoted MC3T3-E1 preosteoblast proliferation and osteogenic differentiation, compared to that in unmodified, phosphate-modified, or calcium-modified Ti-6Al-4V. Furthermore, after implants were inserted into the bone marrow cavity of a rat femur, the osseointegration activity and bond strength between implants and the bone were increased in a phosphate- and calcium-functionalized sample, compared to those in a bare sample.
AB - This study aimed to determine the bioactivities and osseointegration activities of Ti-6Al-4V after surface functionalization with a combination of phosphate and calcium. Several Ti-6Al-4V containing different amounts of phosphate and/or calcium on their surface were prepared. Phosphate was introduced by allowing samples to react with H3PO4, and the resulting phosphate-modified samples were further allowed to react with CaCl2 to obtain phosphate- and calcium-co-immobilized samples. Cell studies revealed that the co-immobilization of phosphate and calcium significantly promoted MC3T3-E1 preosteoblast proliferation and osteogenic differentiation, compared to that in unmodified, phosphate-modified, or calcium-modified Ti-6Al-4V. Furthermore, after implants were inserted into the bone marrow cavity of a rat femur, the osseointegration activity and bond strength between implants and the bone were increased in a phosphate- and calcium-functionalized sample, compared to those in a bare sample.
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U2 - 10.1016/j.matlet.2021.130716
DO - 10.1016/j.matlet.2021.130716
M3 - Article
AN - SCOPUS:85113162022
SN - 0167-577X
VL - 304
JO - Materials Letters
JF - Materials Letters
M1 - 130716
ER -