Impact of osteopenia in liver cirrhosis: Special reference to standard bone mineral density with age

Takeo Toshima; Tomoharu Yoshizumi; Toru Ikegami; Noboru Harada; Shinji Itoh; Yohei Mano; Takashi Motomura; Yuji Soejima; Yoshihiko Maehara

doi:10.21873/anticanres.13009

Impact of osteopenia in liver cirrhosis: Special reference to standard bone mineral density with age

Takeo Toshima, Tomoharu Yoshizumi, Toru Ikegami, Noboru Harada, Shinji Itoh, Yohei Mano, Takashi Motomura, Yuji Soejima, Yoshihiko Maehara

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Background/Aim: Computed tomography (CT) has recently been applied to measure bone mineral density (BMD). However, the definition of osteopenia, which means depletion of BMD, using CT remains controversial. The aim of this study was to establish formulae to calculate standard BMD. Patients and Methods: Fifty healthy donors for liver transplantation underwent CT. BMD was measured as crosssectional average pixel density (Hounsfield units) only in trabecular-bone at Th11 bottom. Validation was performed on another 50 healthy donors to check the accuracy of formulae for standard BMD. Results: Measured BMD was significantly correlated with age in both males and females (p<0.0001). The formulae to calculate standard BMD were 308.82-2.49 × Age in males and 311.84-2.41 × Age in females. Estimated BMD was significantly correlated with measured BMD in males and females (p<0.0001). Conclusion: Osteopenia can be defined by the difference between measured data and calculated data using our new formula based on each age.

Original language	English
Pages (from-to)	6465-6471
Number of pages	7
Journal	Anticancer research
Volume	38
Issue number	11
DOIs	https://doi.org/10.21873/anticanres.13009
Publication status	Published - Nov 2018

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.13009

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title = "Impact of osteopenia in liver cirrhosis: Special reference to standard bone mineral density with age",

abstract = "Background/Aim: Computed tomography (CT) has recently been applied to measure bone mineral density (BMD). However, the definition of osteopenia, which means depletion of BMD, using CT remains controversial. The aim of this study was to establish formulae to calculate standard BMD. Patients and Methods: Fifty healthy donors for liver transplantation underwent CT. BMD was measured as crosssectional average pixel density (Hounsfield units) only in trabecular-bone at Th11 bottom. Validation was performed on another 50 healthy donors to check the accuracy of formulae for standard BMD. Results: Measured BMD was significantly correlated with age in both males and females (p<0.0001). The formulae to calculate standard BMD were 308.82-2.49 × Age in males and 311.84-2.41 × Age in females. Estimated BMD was significantly correlated with measured BMD in males and females (p<0.0001). Conclusion: Osteopenia can be defined by the difference between measured data and calculated data using our new formula based on each age.",

author = "Takeo Toshima and Tomoharu Yoshizumi and Toru Ikegami and Noboru Harada and Shinji Itoh and Yohei Mano and Takashi Motomura and Yuji Soejima and Yoshihiko Maehara",

note = "Funding Information: This study was supported by the following grants: the Program for Basic and Clinical Research on Hepatitis from the Japan Agency for Medical Research and Development, AMED (Numbers 17kf02101077h0001 and 17fk0210305h0003) and JSPS KAKENHI, a Grant-in-Aid from the Ministry of Health, Labour and Welfare, Japan (Numbers JP-16K10577 and JP-16K06432). The funding sources had no role in the collection, analysis, or interpretation of the data, or in the decision to submit the article for publication. Publisher Copyright: {\textcopyright} 2018 International Institute of Anticancer Research.All right reserved.",

year = "2018",

month = nov,

doi = "10.21873/anticanres.13009",

language = "English",

volume = "38",

pages = "6465--6471",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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}

TY - JOUR

T1 - Impact of osteopenia in liver cirrhosis

T2 - Special reference to standard bone mineral density with age

AU - Toshima, Takeo

AU - Yoshizumi, Tomoharu

AU - Ikegami, Toru

AU - Harada, Noboru

AU - Itoh, Shinji

AU - Mano, Yohei

AU - Motomura, Takashi

AU - Soejima, Yuji

AU - Maehara, Yoshihiko

N1 - Funding Information: This study was supported by the following grants: the Program for Basic and Clinical Research on Hepatitis from the Japan Agency for Medical Research and Development, AMED (Numbers 17kf02101077h0001 and 17fk0210305h0003) and JSPS KAKENHI, a Grant-in-Aid from the Ministry of Health, Labour and Welfare, Japan (Numbers JP-16K10577 and JP-16K06432). The funding sources had no role in the collection, analysis, or interpretation of the data, or in the decision to submit the article for publication. Publisher Copyright: © 2018 International Institute of Anticancer Research.All right reserved.

PY - 2018/11

Y1 - 2018/11

N2 - Background/Aim: Computed tomography (CT) has recently been applied to measure bone mineral density (BMD). However, the definition of osteopenia, which means depletion of BMD, using CT remains controversial. The aim of this study was to establish formulae to calculate standard BMD. Patients and Methods: Fifty healthy donors for liver transplantation underwent CT. BMD was measured as crosssectional average pixel density (Hounsfield units) only in trabecular-bone at Th11 bottom. Validation was performed on another 50 healthy donors to check the accuracy of formulae for standard BMD. Results: Measured BMD was significantly correlated with age in both males and females (p<0.0001). The formulae to calculate standard BMD were 308.82-2.49 × Age in males and 311.84-2.41 × Age in females. Estimated BMD was significantly correlated with measured BMD in males and females (p<0.0001). Conclusion: Osteopenia can be defined by the difference between measured data and calculated data using our new formula based on each age.

AB - Background/Aim: Computed tomography (CT) has recently been applied to measure bone mineral density (BMD). However, the definition of osteopenia, which means depletion of BMD, using CT remains controversial. The aim of this study was to establish formulae to calculate standard BMD. Patients and Methods: Fifty healthy donors for liver transplantation underwent CT. BMD was measured as crosssectional average pixel density (Hounsfield units) only in trabecular-bone at Th11 bottom. Validation was performed on another 50 healthy donors to check the accuracy of formulae for standard BMD. Results: Measured BMD was significantly correlated with age in both males and females (p<0.0001). The formulae to calculate standard BMD were 308.82-2.49 × Age in males and 311.84-2.41 × Age in females. Estimated BMD was significantly correlated with measured BMD in males and females (p<0.0001). Conclusion: Osteopenia can be defined by the difference between measured data and calculated data using our new formula based on each age.

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Impact of osteopenia in liver cirrhosis: Special reference to standard bone mineral density with age

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