TY - JOUR
T1 - Impact of lifelong exercise training dose on ventricular-arterial coupling
AU - Hieda, Michinari
AU - Howden, Erin
AU - Shibata, Shigeki
AU - Fujimoto, Naoki
AU - Bhella, Paul S.
AU - Hastings, Jeffrey L.
AU - Tarumi, Takashi
AU - Sarma, Satyam
AU - Fu, Qi
AU - Zhang, Rong
AU - Levine, Benjamin D.
N1 - Funding Information:
This project was supported by the National Institutes of Health grant RO1 AG17479. Drs Hieda, Sarma, and Levine were also supported in part by the American Heart Association Strategically Focused Research Network (14SFRN2060000903). Dr Hieda was also supported by American Heart Association postdoctoral fellowship grant (18POST33960092) and the Harry S. Moss Heart Trust.
Publisher Copyright:
© 2018 American Heart Association, Inc.
PY - 2018
Y1 - 2018
N2 - BACKGROUND: The dynamic Starling mechanism, as assessed by beat-by-beat changes in stroke volume and left ventricular end-diastolic pressure, reflects ventricular-arterial coupling. It deteriorates with age, and is preserved in highly trained masters athletes. Currently, it remains unclear how much exercise over a lifetime is necessary to preserve efficient ventricular-arterial coupling. The purpose of this study was to assess the dose-dependent relationship between lifelong exercise training and the dynamic Starling mechanism in healthy seniors. METHODS: One hundred two seniors were recruited and stratified into 4 groups based on 25 years of exercise training history: sedentary subjects (n=27, <2 sessions/week), casual exercisers (n=25, 2–3 sessions/week), committed exercisers (n=25, 4–5 sessions/week), and competitive Masters Athletes (n=25, 6–7 sessions/week). The dynamic Starling mechanism was estimated by transfer function gain between beat-by-beat changes in diastolic pulmonary artery pressure, a surrogate for left ventricular end-diastolic pressure, and stroke volume index. RESULTS: The transfer function gain of pulmonary artery pressure–stroke volume index was markedly enhanced in committed and competitive exercisers compared with more sedentary seniors and correlated with higher peak oxygen uptake (Vo2) and lower left ventricular stiffness. The power spectral density of pulmonary artery pressure was greater in sedentary adults than in committed and competitive exercisers, whereas the power spectral density of stroke volume index was greater in competitive exercisers than in the other groups. CONCLUSIONS: There is a graded, dose-dependent improvement in ventricular-arterial coupling with increasing amounts of lifelong regular exercise in healthy older individuals. Our data suggest that the optimal dose of lifelong endurance exercise to preserve ventricular-arterial coupling with age appears to be at least 4 to 5 sessions per week.
AB - BACKGROUND: The dynamic Starling mechanism, as assessed by beat-by-beat changes in stroke volume and left ventricular end-diastolic pressure, reflects ventricular-arterial coupling. It deteriorates with age, and is preserved in highly trained masters athletes. Currently, it remains unclear how much exercise over a lifetime is necessary to preserve efficient ventricular-arterial coupling. The purpose of this study was to assess the dose-dependent relationship between lifelong exercise training and the dynamic Starling mechanism in healthy seniors. METHODS: One hundred two seniors were recruited and stratified into 4 groups based on 25 years of exercise training history: sedentary subjects (n=27, <2 sessions/week), casual exercisers (n=25, 2–3 sessions/week), committed exercisers (n=25, 4–5 sessions/week), and competitive Masters Athletes (n=25, 6–7 sessions/week). The dynamic Starling mechanism was estimated by transfer function gain between beat-by-beat changes in diastolic pulmonary artery pressure, a surrogate for left ventricular end-diastolic pressure, and stroke volume index. RESULTS: The transfer function gain of pulmonary artery pressure–stroke volume index was markedly enhanced in committed and competitive exercisers compared with more sedentary seniors and correlated with higher peak oxygen uptake (Vo2) and lower left ventricular stiffness. The power spectral density of pulmonary artery pressure was greater in sedentary adults than in committed and competitive exercisers, whereas the power spectral density of stroke volume index was greater in competitive exercisers than in the other groups. CONCLUSIONS: There is a graded, dose-dependent improvement in ventricular-arterial coupling with increasing amounts of lifelong regular exercise in healthy older individuals. Our data suggest that the optimal dose of lifelong endurance exercise to preserve ventricular-arterial coupling with age appears to be at least 4 to 5 sessions per week.
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U2 - 10.1161/CIRCULATIONAHA.118.035116
DO - 10.1161/CIRCULATIONAHA.118.035116
M3 - Article
C2 - 30571254
AN - SCOPUS:85058919411
SN - 0009-7322
VL - 138
SP - 2638
EP - 2647
JO - Circulation
JF - Circulation
IS - 23
ER -