TY - JOUR
T1 - Impact of hip fracture on all-cause mortality in Japanese patients with type 2 diabetes mellitus
T2 - The Fukuoka Diabetes Registry
AU - Komorita, Yuji
AU - Iwase, Masanori
AU - Idewaki, Yasuhiro
AU - Fujii, Hiroki
AU - Ohkuma, Toshiaki
AU - Ide, Hitoshi
AU - Jodai-Kitamura, Tamaki
AU - Yoshinari, Masahito
AU - Murao-Kimura, Ai
AU - Oku, Yutaro
AU - Nakamura, Udai
AU - Kitazono, Takanari
N1 - Funding Information:
This work was supported in part by The Japan Society for the Promotion of Science KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology of Japan (grant numbers 23249037 and 23659353 to MI and 16K00861 to HF), and the Junior Scientist Development Grant supported by the Japan Diabetes Society (to YK). The authors thank Drs Yutaka Kiyohara, Yasufumi Doi, Toshiharu Ninomiya, Shigenobu Kanba, Dongchon Kang, Shuzo Kumagai, Shinako Kaizu, Yoi-chiro Hirakawa, Chisa Matsumoto, Chie Kitaoka (Kyushu University), Nobutaka Tsutsu, Nobuhiro Sasaki (Fukuoka Red Cross Hospital), Kiyohide Nunoi, Yuichi Sato, Yuji Uchizono, Ayumi Yamauchi, Kaori Itoh, Chie Kono (St. Mary’s Hospital), Sakae Nohara, Hirofumi Imoto, Kazushi Amano, (Steel Memorial Yawata Hospital), Daisuke Gotoh, Toshitaka Himeno, Masae Toyonaga (Kyushu Central Hospital), Noriyasu Shino-hara, Ayako Tsutsumi (Fukuoka Higashi Medical Center), Yasuhiro Idewaki, Masahiro Nakano, Mina Matsuo, Shoko Morimoto, Tomoko Hyodo (Hakujyuji Hospital), Masae Min-ami (Clinic Minami Masae), Miya Wada (Wada Miya Naika Clinic), Yoshifumi Yokomizo (Yokomizo Naika Clinic), Masa-nori Kikuchi, Yohei Kikuchi (Kikuchi Naika Clinic), Riku Nomiyama (Suzuki Naika Clinic), Shin Nakamura (Nakamura Naika Clinic), Kenji Tashiro (Oshima Eye Hospital), Mototaka Yoshinari (Yoshinari Naika Clinic), Kojiro Ichikawa (Fukutsu Naika Clinic), Teruo Omae (Hisayama Research Institute For Lifestyle Diseases), Hiroaki Ooboshi and Shigeru Tanaka (Fukuoka Dental College). The authors also thank the clinical research coordinators, Chiho Ohba (Hisayama Research Institute For Lifestyle Diseases), Kayoko Sekioka and Yoko Nishioka (Kyushu University); and those in the administration office, Tomoko Matake (Hisayama Research Institute For Lifestyle Diseases) and Junko Ishimatsu (Kyushu University). Finally, the authors thank Edanz Group (www.edanzediting.co.jp) for editing a draft of this manuscript.
Funding Information:
This work was supported in part by The Japan Society for the Promotion of Science KAKENHI from the Ministry of Education, Culture, Sports, Science and Technology of Japan (grant numbers 23249037 and 23659353 to MI and 16K00861 to HF), and the Junior Scientist Development Grant supported by the Japan Diabetes Society (to YK). The authors thank Drs Yutaka Kiyohara, Yasufumi Doi, Toshiharu Ninomiya, Shigenobu Kanba, Dongchon Kang, Shuzo Kumagai, Shinako Kaizu, Yoichiro Hirakawa, Chisa Matsumoto, Chie Kitaoka (Kyushu University), Nobutaka Tsutsu, Nobuhiro Sasaki (Fukuoka Red Cross Hospital), Kiyohide Nunoi, Yuichi Sato, Yuji Uchizono, Ayumi Yamauchi, Kaori Itoh, Chie Kono (St. Mary's Hospital), Sakae Nohara, Hirofumi Imoto, Kazushi Amano, (Steel Memorial Yawata Hospital), Daisuke Gotoh, Toshitaka Himeno, Masae Toyonaga (Kyushu Central Hospital), Noriyasu Shinohara, Ayako Tsutsumi (Fukuoka Higashi Medical Center), Yasuhiro Idewaki, Masahiro Nakano, Mina Matsuo, Shoko Morimoto, Tomoko Hyodo (Hakujyuji Hospital), Masae Minami (Clinic Minami Masae), Miya Wada (Wada Miya Naika Clinic), Yoshifumi Yokomizo (Yokomizo Naika Clinic), Masanori Kikuchi, Yohei Kikuchi (Kikuchi Naika Clinic), Riku Nomiyama (Suzuki Naika Clinic), Shin Nakamura (Nakamura Naika Clinic), Kenji Tashiro (Oshima Eye Hospital), Mototaka Yoshinari (Yoshinari Naika Clinic), Kojiro Ichikawa (Fukutsu Naika Clinic), Teruo Omae (Hisayama Research Institute For Lifestyle Diseases), Hiroaki Ooboshi and Shigeru Tanaka (Fukuoka Dental College). The authors also thank the clinical research coordinators, Chiho Ohba (Hisayama Research Institute For Lifestyle Diseases), Kayoko Sekioka and Yoko Nishioka (Kyushu University); and those in the administration office, Tomoko Matake (Hisayama Research Institute For Lifestyle Diseases) and Junko Ishimatsu (Kyushu University). Finally, the authors thank Edanz Group (www.edanzediting.co.jp) for editing a draft of this manuscript.
Publisher Copyright:
© 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Aims/Introduction: Patients with type 2 diabetes mellitus have an increased hip fracture risk. We investigated the relationship between hip fracture and all-cause death in patients with type 2 diabetes in comparison with cardiovascular disease (CVD) or end-stage renal disease (ERSD). Materials and Methods: In total, 4,923 Japanese participants with type 2 diabetes (mean age 65 years, 2,790 men, 2,133 women) were followed for a median of 5.3 years (follow-up rate 99.5%). We evaluated the associations between the presence of hip fracture (n = 110), upper limb fracture (n = 801), CVD (n = 1,344), ESRD (n = 104) and all-cause death by logistic regression analysis. Results: A total of 309 participants died during follow up. Multivariate-adjusted odds ratios (ORs) for all-cause mortality were significantly higher in participants with hip fractures than those without hip fractures (OR 2.67, 95% confidence interval [CI] 1.54–4.41), whereas the ORs for upper limb fracture were not significant. The ORs for all-cause mortality were significantly higher in participants with CVD than those without CVD (OR 1.78, 95% CI, 1.39–2.70) and ESRD (OR 2.36, 95% CI 1.32–4.05). The ORs for all-cause mortality of hip fracture were not affected by further adjustment for CVD and ESRD (OR 2.74, 95% CI 1.58–4.54). The cause of death was infection (40.0%), malignant neoplasm (25.0%) and CVD (15.0%) among participants with hip fracture. Conclusions: Hip fractures were associated with an increased risk of death among Japanese patients with type 2 diabetes, independently of CVD and ESRD.
AB - Aims/Introduction: Patients with type 2 diabetes mellitus have an increased hip fracture risk. We investigated the relationship between hip fracture and all-cause death in patients with type 2 diabetes in comparison with cardiovascular disease (CVD) or end-stage renal disease (ERSD). Materials and Methods: In total, 4,923 Japanese participants with type 2 diabetes (mean age 65 years, 2,790 men, 2,133 women) were followed for a median of 5.3 years (follow-up rate 99.5%). We evaluated the associations between the presence of hip fracture (n = 110), upper limb fracture (n = 801), CVD (n = 1,344), ESRD (n = 104) and all-cause death by logistic regression analysis. Results: A total of 309 participants died during follow up. Multivariate-adjusted odds ratios (ORs) for all-cause mortality were significantly higher in participants with hip fractures than those without hip fractures (OR 2.67, 95% confidence interval [CI] 1.54–4.41), whereas the ORs for upper limb fracture were not significant. The ORs for all-cause mortality were significantly higher in participants with CVD than those without CVD (OR 1.78, 95% CI, 1.39–2.70) and ESRD (OR 2.36, 95% CI 1.32–4.05). The ORs for all-cause mortality of hip fracture were not affected by further adjustment for CVD and ESRD (OR 2.74, 95% CI 1.58–4.54). The cause of death was infection (40.0%), malignant neoplasm (25.0%) and CVD (15.0%) among participants with hip fracture. Conclusions: Hip fractures were associated with an increased risk of death among Japanese patients with type 2 diabetes, independently of CVD and ESRD.
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U2 - 10.1111/jdi.13076
DO - 10.1111/jdi.13076
M3 - Article
C2 - 31111663
AN - SCOPUS:85067391582
SN - 2040-1116
VL - 11
SP - 62
EP - 69
JO - Journal of Diabetes Investigation
JF - Journal of Diabetes Investigation
IS - 1
ER -
