Immunotherapy approaches targeting regulatory T-cells

Hideya Onishi, Takashi Morisaki, Mitsuo Katano

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)


The immune system prevents establishment and progression of cancer through innate and adaptive surveillance. However, some cancerous cells successfully evade the immune system. Regulatory T-cells (Tregs) facilitate such evasion. Tregs may be the factor responsible for the limited success of human tumor immunotherapy to date. To improve immunotherapy, it is thought that the number of Tregs and their functions should be inhibited in patients with advanced cancer. In this review, we focus on recent immunotherapy efforts targeting Tregs.

Original languageEnglish
Pages (from-to)997-1003
Number of pages7
JournalAnticancer research
Issue number3
Publication statusPublished - Mar 2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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