Immunohistological Localization of Peroxisome Proliferator-Activated Receptor α and γ in Human Sebaceous Glands

Masutaka Furue; Masaki Takemura; Kiichiroet Nishio; Yuki Sato; Shoko Nagata; Nagisa Kan; Asako Suenaga; Kazuhisa Furue; Maiko Yoshida; Sawako Konishi; Gaku Tsuji

Immunohistological Localization of Peroxisome Proliferator-Activated Receptor α and γ in Human Sebaceous Glands

Masutaka Furue, Masaki Takemura, Kiichiroet Nishio, Yuki Sato, Shoko Nagata, Nagisa Kan, Asako Suenaga, Kazuhisa Furue, Maiko Yoshida, Sawako Konishi, Gaku Tsuji

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4 Citations (Scopus)

Abstract

The immunohistological localization of peroxisome proliferator-activated receptor a (PPARa) and PPAR g was examined in 28 pilosebaceous units in 10 paraffin-embedded normal human skin specimens. Rabbit polyclonal antibody against human PPARa and monoclonal antibody against human PPARg were used as specific primary antibodies. The nuclear and cytoplasmic expression of PPARa was detected in basal to differentiated sebocytes. In contrast, the expression of PPARg was confined to nuclei of suprabasal to early-differentiated sebocytes. The nuclear PPARg expression was present only occasionally in the basal sebocytes. These results suggest that PPARa and PPARg are integral parts of sebocyte differentiation in human sebaceous glands.

Original language	English
Pages (from-to)	199-203
Number of pages	5
Journal	Fukuoka igaku zasshi = Hukuoka acta medica
Volume	107
Issue number	11
Publication status	Published - Nov 1 2016

All Science Journal Classification (ASJC) codes

Medicine(all)

Cite this

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title = "Immunohistological Localization of Peroxisome Proliferator-Activated Receptor α and γ in Human Sebaceous Glands",

abstract = "The immunohistological localization of peroxisome proliferator-activated receptor a (PPARa) and PPAR g was examined in 28 pilosebaceous units in 10 paraffin-embedded normal human skin specimens. Rabbit polyclonal antibody against human PPARa and monoclonal antibody against human PPARg were used as specific primary antibodies. The nuclear and cytoplasmic expression of PPARa was detected in basal to differentiated sebocytes. In contrast, the expression of PPARg was confined to nuclei of suprabasal to early-differentiated sebocytes. The nuclear PPARg expression was present only occasionally in the basal sebocytes. These results suggest that PPARa and PPARg are integral parts of sebocyte differentiation in human sebaceous glands.",

author = "Masutaka Furue and Masaki Takemura and Kiichiroet Nishio and Yuki Sato and Shoko Nagata and Nagisa Kan and Asako Suenaga and Kazuhisa Furue and Maiko Yoshida and Sawako Konishi and Gaku Tsuji",

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T1 - Immunohistological Localization of Peroxisome Proliferator-Activated Receptor α and γ in Human Sebaceous Glands

AU - Furue, Masutaka

AU - Takemura, Masaki

AU - Nishio, Kiichiroet

AU - Sato, Yuki

AU - Nagata, Shoko

AU - Kan, Nagisa

AU - Suenaga, Asako

AU - Furue, Kazuhisa

AU - Yoshida, Maiko

AU - Konishi, Sawako

AU - Tsuji, Gaku

PY - 2016/11/1

Y1 - 2016/11/1

N2 - The immunohistological localization of peroxisome proliferator-activated receptor a (PPARa) and PPAR g was examined in 28 pilosebaceous units in 10 paraffin-embedded normal human skin specimens. Rabbit polyclonal antibody against human PPARa and monoclonal antibody against human PPARg were used as specific primary antibodies. The nuclear and cytoplasmic expression of PPARa was detected in basal to differentiated sebocytes. In contrast, the expression of PPARg was confined to nuclei of suprabasal to early-differentiated sebocytes. The nuclear PPARg expression was present only occasionally in the basal sebocytes. These results suggest that PPARa and PPARg are integral parts of sebocyte differentiation in human sebaceous glands.

AB - The immunohistological localization of peroxisome proliferator-activated receptor a (PPARa) and PPAR g was examined in 28 pilosebaceous units in 10 paraffin-embedded normal human skin specimens. Rabbit polyclonal antibody against human PPARa and monoclonal antibody against human PPARg were used as specific primary antibodies. The nuclear and cytoplasmic expression of PPARa was detected in basal to differentiated sebocytes. In contrast, the expression of PPARg was confined to nuclei of suprabasal to early-differentiated sebocytes. The nuclear PPARg expression was present only occasionally in the basal sebocytes. These results suggest that PPARa and PPARg are integral parts of sebocyte differentiation in human sebaceous glands.

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JO - Fukuoka igaku zasshi = Hukuoka acta medica

JF - Fukuoka igaku zasshi = Hukuoka acta medica

IS - 11

ER -

Immunohistological Localization of Peroxisome Proliferator-Activated Receptor α and γ in Human Sebaceous Glands

Abstract

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