Immunohistological Expression of p16INK4a is Commonly Present Both in Benign and Malignant Sweat Gland Neoplasias

Jun Tsujita, Yumiko Kaku, Toshio Ichiki, ayaka eto, Hiromi Maemura, Akiko Otsuka, Risa Nakaie, Noriko Kitagawa, Yuka Morioka, Tomoyo Matsuda, Maiko Yoshida, Masutaka Furue

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3 Citations (Scopus)


The expression of p16INK4a has been reported to be a significant marker for malignant transformation of epidermal tumors. However, little is known about sweat gland tumors. We examined the immunohistological expression of p16INK4a in benign and malignant sweat gland tumors. The ductal and acrosyringial portion of normal eccrine glands were positively stained with p16INK4a while it was negative in the normal epidermis. Moderate to strong expression of p16INK4a was found in 16 of 17 eccrine poromas, 4 of 5 hidradenomas, 3 of 3 syringocystadenoma papilliferums, 2 of 2 mixed tumors, and 3 of 3 syringomas. The p16INK4a expression was observed focally or diffusely in 4 of 4 porocarcinomas, 4 of 4 apocrine carcinomas and 12 of 17 extramammary Paget's diseases. We conclude that the p16INK4a expression is not a good marker for dictating malignant transformation of sweat gland tumors.

Original languageEnglish
Pages (from-to)323-329
Number of pages7
JournalFukuoka igaku zasshi = Hukuoka acta medica
Issue number12
Publication statusPublished - Dec 1 2015

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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