Immunohistochemical expression of epidermal growth factor receptor in breast cancer

Tadahiro Nozoe, Emiko Mori, Tomohiro Iguchi, Akinori Egashira, Eisuke Adachi, Akito Matsukuma, Takahiro Ezaki

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Background: Molecular-targeting drugs able to treat breast cancer expressing epidermal growth factor receptor (EGFR) would be clinically valuable. The aim of the current study was to determine the further significance of immunohistochemical expression of EGFR in breast cancer. Methods: The immunohistochemical expression of EGFR was examined in 37 women with breast cancer who had been treated with surgical resection. Relationship of EGFR expression and clinicopathological characteristics was investigated. Results: EGFR expression proved to be comparatively more frequent among triple-negative (estrogen receptor negative, progesterone receptor negative, and human epidermal growth factor receptor 2 negative) breast cancers (P = 0.067). Conclusions: Knowledge of a patient's immunohistochemical EGFR expression, which could be one of the key molecular findings related to molecular-targeting therapy, might be useful information to treat triple-negative breast cancer.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalBreast Cancer
Issue number1
Publication statusPublished - Jan 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)


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