TY - JOUR
T1 - Immunohistochemical evaluation of squamous cell carcinoma antigen and s‐100 protein‐positive cells in human malignant esophageal tissues
AU - Matsuda, Hiroyuki
AU - Mori, Masaki
AU - Tsujitani, Shunichi
AU - Ohno, Shinji
AU - Kuwano, Hiroyuki
AU - Sugimachi, Keizo
PY - 1990/5/15
Y1 - 1990/5/15
N2 - Localization and intensity of squamous cell carcinoma‐related antigen (SCC‐Ag) and infiltration of Langerhans' cells (LC) were investigated immunohistochemically, using anti‐SCC‐Ag and anti‐S‐100 protein antisera, respectively, in 36 cases of squamous cell carcinoma of the human esophagus. The SCC‐Ag was an indicator of histologic differentiation of squamous cell carcinoma but not of malignant potential. The population density of LC correlated well with the histologic stage, vessel invasion, and postoperative survival time. In patients with a marked infiltration of LC, survival time was longer than for those in whom the infiltration was slight (P < 0.05). The density of the LC can serve an indicator of defense of the host against the carcinoma. There was no correlation between SCC‐Ag and S‐100 protein‐positive cells.
AB - Localization and intensity of squamous cell carcinoma‐related antigen (SCC‐Ag) and infiltration of Langerhans' cells (LC) were investigated immunohistochemically, using anti‐SCC‐Ag and anti‐S‐100 protein antisera, respectively, in 36 cases of squamous cell carcinoma of the human esophagus. The SCC‐Ag was an indicator of histologic differentiation of squamous cell carcinoma but not of malignant potential. The population density of LC correlated well with the histologic stage, vessel invasion, and postoperative survival time. In patients with a marked infiltration of LC, survival time was longer than for those in whom the infiltration was slight (P < 0.05). The density of the LC can serve an indicator of defense of the host against the carcinoma. There was no correlation between SCC‐Ag and S‐100 protein‐positive cells.
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U2 - 10.1002/1097-0142(19900515)65:10<2261::AID-CNCR2820651017>3.0.CO;2-8
DO - 10.1002/1097-0142(19900515)65:10<2261::AID-CNCR2820651017>3.0.CO;2-8
M3 - Article
C2 - 2346911
AN - SCOPUS:0025276889
SN - 0008-543X
VL - 65
SP - 2261
EP - 2265
JO - Cancer
JF - Cancer
IS - 10
ER -
