Immunohistochemical detection of extravasated fibrinogen (fibrin) in human diabetic retina

Toshinori Murata, Tatsuro Ishibashi, Hajime Inomata

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


In diabetic retinopathy, breakdown of the blood-retinal barrier is an early functional disorder that can cause retinal edema, which in turn results in visual disturbance. Hard exudates, composed mainly of lipid and proteinaceous material, are one sign of chronic retinal edema caused by long-standing leakage from the vessels due to breakdown of the blood-retinal barrier. Utilizing diabetic retinas in which hard exudates were present, we performed immunohistochemical staining for fibrinogen. Because fibrinogen is a serum protein, its extravascular localization implies the existence of blood-retinal barrier breakdown. Our studies showed that the extravasated fibrinogen from blood-retinal barrier breakdown accumulated in the hard exudates and in areas of hemorrhage found primarily in the outer plexiform layer and was then phagocytosed by macrophages.

Original languageEnglish
Pages (from-to)428-431
Number of pages4
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number5
Publication statusPublished - Aug 1992

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Immunohistochemical detection of extravasated fibrinogen (fibrin) in human diabetic retina'. Together they form a unique fingerprint.

Cite this