Immunohistochemical demonstration of bcl-2 protein in ameloblastoma

Takeshi Mitsuyasu, Hidemitsu Harada, Yoshinori Higuchi, Ken Ichi Kimura, Norifumi Nakamura, Takeshi Katsuki, Eiro Kubota, Kuniaki Toyoshima, Masamichi Ohishi

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44 Citations (Scopus)


The bcl-2 gene is known through its product, bcl-2 protein, which prevents apoptosis, and also by its expression in development, especially in sites characterized by epithelial-mesenchymal interactions. In the developing tooth germ, bcl-2-protein is expressed in the epithelial component. In this study, we examined the expression of bcl-2 protein immunohistochemically in 25 ameloblastomas using a monoclonal antibody against anti-human bcl-2 oncoprotein. In all 25 cases, bcl-2 protein was found mainly in the outer layer of tumor cells, whereas the inner cells (stellate reticulum-like cells and squamoid cells) were negative. The bcl-2 protein is therefore thought to play a role in maintaining the stem-cell population in the peripheral layers of the tumor nests from which proliferating cells can be recruited.

Original languageEnglish
Pages (from-to)345-348
Number of pages4
JournalJournal of Oral Pathology and Medicine
Issue number8
Publication statusPublished - Sept 1997

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


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