Immunohistochemical demonstration of bcl-2 protein in ameloblastoma

Takeshi Mitsuyasu; Hidemitsu Harada; Yoshinori Higuchi; Ken Ichi Kimura; Norifumi Nakamura; Takeshi Katsuki; Eiro Kubota; Kuniaki Toyoshima; Masamichi Ohishi

doi:10.1111/j.1600-0714.1997.tb00228.x

Immunohistochemical demonstration of bcl-2 protein in ameloblastoma

Takeshi Mitsuyasu, Hidemitsu Harada, Yoshinori Higuchi, Ken Ichi Kimura, Norifumi Nakamura, Takeshi Katsuki, Eiro Kubota, Kuniaki Toyoshima, Masamichi Ohishi

Oral Surgery

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

The bcl-2 gene is known through its product, bcl-2 protein, which prevents apoptosis, and also by its expression in development, especially in sites characterized by epithelial-mesenchymal interactions. In the developing tooth germ, bcl-2-protein is expressed in the epithelial component. In this study, we examined the expression of bcl-2 protein immunohistochemically in 25 ameloblastomas using a monoclonal antibody against anti-human bcl-2 oncoprotein. In all 25 cases, bcl-2 protein was found mainly in the outer layer of tumor cells, whereas the inner cells (stellate reticulum-like cells and squamoid cells) were negative. The bcl-2 protein is therefore thought to play a role in maintaining the stem-cell population in the peripheral layers of the tumor nests from which proliferating cells can be recruited.

Original language	English
Pages (from-to)	345-348
Number of pages	4
Journal	Journal of Oral Pathology and Medicine
Volume	26
Issue number	8
DOIs	https://doi.org/10.1111/j.1600-0714.1997.tb00228.x
Publication status	Published - Sept 1997

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Oral Surgery
Otorhinolaryngology
Cancer Research
Periodontics

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0714.1997.tb00228.x

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title = "Immunohistochemical demonstration of bcl-2 protein in ameloblastoma",

abstract = "The bcl-2 gene is known through its product, bcl-2 protein, which prevents apoptosis, and also by its expression in development, especially in sites characterized by epithelial-mesenchymal interactions. In the developing tooth germ, bcl-2-protein is expressed in the epithelial component. In this study, we examined the expression of bcl-2 protein immunohistochemically in 25 ameloblastomas using a monoclonal antibody against anti-human bcl-2 oncoprotein. In all 25 cases, bcl-2 protein was found mainly in the outer layer of tumor cells, whereas the inner cells (stellate reticulum-like cells and squamoid cells) were negative. The bcl-2 protein is therefore thought to play a role in maintaining the stem-cell population in the peripheral layers of the tumor nests from which proliferating cells can be recruited.",

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AU - Mitsuyasu, Takeshi

AU - Harada, Hidemitsu

AU - Higuchi, Yoshinori

AU - Kimura, Ken Ichi

AU - Nakamura, Norifumi

AU - Katsuki, Takeshi

AU - Kubota, Eiro

AU - Toyoshima, Kuniaki

AU - Ohishi, Masamichi

PY - 1997/9

Y1 - 1997/9

N2 - The bcl-2 gene is known through its product, bcl-2 protein, which prevents apoptosis, and also by its expression in development, especially in sites characterized by epithelial-mesenchymal interactions. In the developing tooth germ, bcl-2-protein is expressed in the epithelial component. In this study, we examined the expression of bcl-2 protein immunohistochemically in 25 ameloblastomas using a monoclonal antibody against anti-human bcl-2 oncoprotein. In all 25 cases, bcl-2 protein was found mainly in the outer layer of tumor cells, whereas the inner cells (stellate reticulum-like cells and squamoid cells) were negative. The bcl-2 protein is therefore thought to play a role in maintaining the stem-cell population in the peripheral layers of the tumor nests from which proliferating cells can be recruited.

AB - The bcl-2 gene is known through its product, bcl-2 protein, which prevents apoptosis, and also by its expression in development, especially in sites characterized by epithelial-mesenchymal interactions. In the developing tooth germ, bcl-2-protein is expressed in the epithelial component. In this study, we examined the expression of bcl-2 protein immunohistochemically in 25 ameloblastomas using a monoclonal antibody against anti-human bcl-2 oncoprotein. In all 25 cases, bcl-2 protein was found mainly in the outer layer of tumor cells, whereas the inner cells (stellate reticulum-like cells and squamoid cells) were negative. The bcl-2 protein is therefore thought to play a role in maintaining the stem-cell population in the peripheral layers of the tumor nests from which proliferating cells can be recruited.

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Immunohistochemical demonstration of bcl-2 protein in ameloblastoma

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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