IL-15 is elevated in the patients of postoperative enterocolitis

Toshihiko Mayumi; Jun Takezawa; Hideo Takahashi; Haruo Yamaguchi; Hitoshi Nishimura; Atsushi Enomoto; Satoshi Ichiyama; Yasunobu Yoshikai

doi:10.1006/cyto.1999.0494

IL-15 is elevated in the patients of postoperative enterocolitis

Toshihiko Mayumi, Jun Takezawa, Hideo Takahashi, Haruo Yamaguchi, Hitoshi Nishimura, Atsushi Enomoto, Satoshi Ichiyama, Yasunobu Yoshikai

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Serum interleukin 15 (IL-15) levels were measured in 77 patients who were consecutively admitted to our intensive care unit. Postoperative enterocolitis occurred in four patients and Methicillin-resistant Staphylococcus aureus (MRSA), but not Clostridium defficile, was identified in the faecal specimens from these patients. The IL-15 levels in the patients with MRSA enterocolitis were significantly elevated compared with those of other MRSA infections without enterocolitis including pneumonia (n = 6) and cholangitis (n = 1), and other MRSA non-colonized patients (n = 66) (21.2 ± 5.2 pg/ml vs 4.3 ± 0.2, 4.3 ± 0.5). Notably, an increase in serum IL-15 was observed just before clinical manifestation of severe diarrhoea. Our findings suggest that IL-15 may be associated in the pathogenesis of postoperative enterocolitis and its serum level may be a severity indicator of the disease.

Original language	English
Pages (from-to)	888-893
Number of pages	6
Journal	Cytokine
Volume	11
Issue number	11
DOIs	https://doi.org/10.1006/cyto.1999.0494
Publication status	Published - Nov 1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Hematology
Biochemistry
Immunology and Allergy
Immunology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1006/cyto.1999.0494

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title = "IL-15 is elevated in the patients of postoperative enterocolitis",

abstract = "Serum interleukin 15 (IL-15) levels were measured in 77 patients who were consecutively admitted to our intensive care unit. Postoperative enterocolitis occurred in four patients and Methicillin-resistant Staphylococcus aureus (MRSA), but not Clostridium defficile, was identified in the faecal specimens from these patients. The IL-15 levels in the patients with MRSA enterocolitis were significantly elevated compared with those of other MRSA infections without enterocolitis including pneumonia (n = 6) and cholangitis (n = 1), and other MRSA non-colonized patients (n = 66) (21.2 ± 5.2 pg/ml vs 4.3 ± 0.2, 4.3 ± 0.5). Notably, an increase in serum IL-15 was observed just before clinical manifestation of severe diarrhoea. Our findings suggest that IL-15 may be associated in the pathogenesis of postoperative enterocolitis and its serum level may be a severity indicator of the disease.",

author = "Toshihiko Mayumi and Jun Takezawa and Hideo Takahashi and Haruo Yamaguchi and Hitoshi Nishimura and Atsushi Enomoto and Satoshi Ichiyama and Yasunobu Yoshikai",

year = "1999",

month = nov,

doi = "10.1006/cyto.1999.0494",

language = "English",

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T1 - IL-15 is elevated in the patients of postoperative enterocolitis

AU - Mayumi, Toshihiko

AU - Takezawa, Jun

AU - Takahashi, Hideo

AU - Yamaguchi, Haruo

AU - Nishimura, Hitoshi

AU - Enomoto, Atsushi

AU - Ichiyama, Satoshi

AU - Yoshikai, Yasunobu

PY - 1999/11

Y1 - 1999/11

N2 - Serum interleukin 15 (IL-15) levels were measured in 77 patients who were consecutively admitted to our intensive care unit. Postoperative enterocolitis occurred in four patients and Methicillin-resistant Staphylococcus aureus (MRSA), but not Clostridium defficile, was identified in the faecal specimens from these patients. The IL-15 levels in the patients with MRSA enterocolitis were significantly elevated compared with those of other MRSA infections without enterocolitis including pneumonia (n = 6) and cholangitis (n = 1), and other MRSA non-colonized patients (n = 66) (21.2 ± 5.2 pg/ml vs 4.3 ± 0.2, 4.3 ± 0.5). Notably, an increase in serum IL-15 was observed just before clinical manifestation of severe diarrhoea. Our findings suggest that IL-15 may be associated in the pathogenesis of postoperative enterocolitis and its serum level may be a severity indicator of the disease.

AB - Serum interleukin 15 (IL-15) levels were measured in 77 patients who were consecutively admitted to our intensive care unit. Postoperative enterocolitis occurred in four patients and Methicillin-resistant Staphylococcus aureus (MRSA), but not Clostridium defficile, was identified in the faecal specimens from these patients. The IL-15 levels in the patients with MRSA enterocolitis were significantly elevated compared with those of other MRSA infections without enterocolitis including pneumonia (n = 6) and cholangitis (n = 1), and other MRSA non-colonized patients (n = 66) (21.2 ± 5.2 pg/ml vs 4.3 ± 0.2, 4.3 ± 0.5). Notably, an increase in serum IL-15 was observed just before clinical manifestation of severe diarrhoea. Our findings suggest that IL-15 may be associated in the pathogenesis of postoperative enterocolitis and its serum level may be a severity indicator of the disease.

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DO - 10.1006/cyto.1999.0494

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JO - Cytokine

JF - Cytokine

IS - 11

ER -

IL-15 is elevated in the patients of postoperative enterocolitis

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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