Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion

Mio Yano; Toshihiko Imamura; Daisuke Asai; Nobutaka Kiyokawa; Kazuhiko Nakabayashi; Kenji Matsumoto; Takao Deguchi; Yoshiko Hashii; Yu ko Honda; Daiichiro Hasegawa; Yoji Sasahara; Mutsuo Ishii; Yoshiyuki Kosaka; Koji Kato; Midori Shima; Hiroki Hori; Keiko Yumura-Yagi; Junichi Hara; Megumi Oda; Keizo Horibe; Hitoshi Ichikawa; Atsushi Sato

doi:10.1111/bjh.13757

Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion

Mio Yano, Toshihiko Imamura, Daisuke Asai, Nobutaka Kiyokawa, Kazuhiko Nakabayashi, Kenji Matsumoto, Takao Deguchi, Yoshiko Hashii, Yu ko Honda, Daiichiro Hasegawa, Yoji Sasahara, Mutsuo Ishii, Yoshiyuki Kosaka, Koji Kato, Midori Shima, Hiroki Hori, Keiko Yumura-Yagi, Junichi Hara, Megumi Oda, Keizo HoribeHitoshi Ichikawa, Atsushi Sato

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Activating tyrosine kinase mutations or cytokine receptor signalling alterations have attracted attention as therapeutic targets for high-risk paediatric acute lymphoblastic leukaemia (ALL). We identified two novel kinase fusions, OFD1-JAK2 and NCOR1-LYN, in paediatric ALL patients with IKZF1 deletion, by mRNA sequencing. The patient with CSF2RA-CRLF2 also harboured IGH-EPOR. All these patients had high-risk features, such as high initial white blood cell counts and initial poor response to prednisolone. The functional analysis of these novel fusions is on-going to determine whether these genetic alterations can be targeted by drugs.

Original language	English
Pages (from-to)	813-817
Number of pages	5
Journal	British Journal of Haematology
Volume	171
Issue number	5
DOIs	https://doi.org/10.1111/bjh.13757
Publication status	Published - Dec 1 2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hematology

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10.1111/bjh.13757

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Yano, M., Imamura, T., Asai, D., Kiyokawa, N., Nakabayashi, K., Matsumoto, K., Deguchi, T., Hashii, Y., Honda, Y. K., Hasegawa, D., Sasahara, Y., Ishii, M., Kosaka, Y., Kato, K., Shima, M., Hori, H., Yumura-Yagi, K., Hara, J., Oda, M., ... Sato, A. (2015). Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion. British Journal of Haematology, 171(5), 813-817. https://doi.org/10.1111/bjh.13757

Yano, M, Imamura, T, Asai, D, Kiyokawa, N, Nakabayashi, K, Matsumoto, K, Deguchi, T, Hashii, Y, Honda, YK, Hasegawa, D, Sasahara, Y, Ishii, M, Kosaka, Y, Kato, K, Shima, M, Hori, H, Yumura-Yagi, K, Hara, J, Oda, M, Horibe, K, Ichikawa, H & Sato, A 2015, 'Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion', British Journal of Haematology, vol. 171, no. 5, pp. 813-817. https://doi.org/10.1111/bjh.13757

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title = "Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion",

abstract = "Activating tyrosine kinase mutations or cytokine receptor signalling alterations have attracted attention as therapeutic targets for high-risk paediatric acute lymphoblastic leukaemia (ALL). We identified two novel kinase fusions, OFD1-JAK2 and NCOR1-LYN, in paediatric ALL patients with IKZF1 deletion, by mRNA sequencing. The patient with CSF2RA-CRLF2 also harboured IGH-EPOR. All these patients had high-risk features, such as high initial white blood cell counts and initial poor response to prednisolone. The functional analysis of these novel fusions is on-going to determine whether these genetic alterations can be targeted by drugs.",

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AU - Yano, Mio

AU - Imamura, Toshihiko

AU - Asai, Daisuke

AU - Kiyokawa, Nobutaka

AU - Nakabayashi, Kazuhiko

AU - Matsumoto, Kenji

AU - Deguchi, Takao

AU - Hashii, Yoshiko

AU - Honda, Yu ko

AU - Hasegawa, Daiichiro

AU - Sasahara, Yoji

AU - Ishii, Mutsuo

AU - Kosaka, Yoshiyuki

AU - Kato, Koji

AU - Shima, Midori

AU - Hori, Hiroki

AU - Yumura-Yagi, Keiko

AU - Hara, Junichi

AU - Oda, Megumi

AU - Horibe, Keizo

AU - Ichikawa, Hitoshi

AU - Sato, Atsushi

PY - 2015/12/1

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AB - Activating tyrosine kinase mutations or cytokine receptor signalling alterations have attracted attention as therapeutic targets for high-risk paediatric acute lymphoblastic leukaemia (ALL). We identified two novel kinase fusions, OFD1-JAK2 and NCOR1-LYN, in paediatric ALL patients with IKZF1 deletion, by mRNA sequencing. The patient with CSF2RA-CRLF2 also harboured IGH-EPOR. All these patients had high-risk features, such as high initial white blood cell counts and initial poor response to prednisolone. The functional analysis of these novel fusions is on-going to determine whether these genetic alterations can be targeted by drugs.

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Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion

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