Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure

Hirokazu Tamamura; Akio Ojida; Teppei Ogawa; Hiroshi Tsutsumi; Hiroyuki Masuno; Hideki Nakashima; Naoki Yamamoto; Itaru Hamachi; Nobutaka Fujii

doi:10.1021/jm060025u

Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure

Hirokazu Tamamura, Akio Ojida, Teppei Ogawa, Hiroshi Tsutsumi, Hiroyuki Masuno, Hideki Nakashima, Naoki Yamamoto, Itaru Hamachi, Nobutaka Fujii

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Several low molecular weight nonpeptide compounds having the dipicolylamine-zinc(II) complex structure were identified as potent and selective antagonists of the chemokine receptor CXCR4. These compounds showed strong inhibitory activity against CXCL12 binding to CXCR4, and the top compound exhibited significant anti-HIV activity. Zinc(II)-dipicolylamine unit-containing compounds proved to be useful and attractive lead compounds for chemotherapy of these diseases as nonpeptide CXCR4 antagonists possessing the novel scaffold structure.

Original language	English
Pages (from-to)	3412-3415
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	49
Issue number	11
DOIs	https://doi.org/10.1021/jm060025u
Publication status	Published - Jun 1 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/jm060025u

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AU - Tamamura, Hirokazu

AU - Ojida, Akio

AU - Ogawa, Teppei

AU - Tsutsumi, Hiroshi

AU - Masuno, Hiroyuki

AU - Nakashima, Hideki

AU - Yamamoto, Naoki

AU - Hamachi, Itaru

AU - Fujii, Nobutaka

PY - 2006/6/1

Y1 - 2006/6/1

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AB - Several low molecular weight nonpeptide compounds having the dipicolylamine-zinc(II) complex structure were identified as potent and selective antagonists of the chemokine receptor CXCR4. These compounds showed strong inhibitory activity against CXCL12 binding to CXCR4, and the top compound exhibited significant anti-HIV activity. Zinc(II)-dipicolylamine unit-containing compounds proved to be useful and attractive lead compounds for chemotherapy of these diseases as nonpeptide CXCR4 antagonists possessing the novel scaffold structure.

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IS - 11

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Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure

Abstract

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UN SDGs

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