TY - JOUR
T1 - Identification of a frameshift mutation resulting in premature termination and loss of cell wall anchoring of the PAc antigen of Streptococcus mutans GS-5
AU - Murakami, Y.
AU - Nakano, Y.
AU - Yamashita, Y.
AU - Koga, T.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1997
Y1 - 1997
N2 - Most strains of Streptococcus mutans possess a 190-kDa protein antigen (PAc) on their cell surfaces, while strain GS-5 produces extracellularly a 155-kDa PAc protein. The pac gene of strain GS-5 consists of 3,477 bp and codes for a protein of 1,158 amino acids. One insertion of an adenine into the 3,469th, 3,470th, or 3,471st position from the start codon results in a frameshift mutation at codon 1157 with subsequent termination after 3 additional codons.
AB - Most strains of Streptococcus mutans possess a 190-kDa protein antigen (PAc) on their cell surfaces, while strain GS-5 produces extracellularly a 155-kDa PAc protein. The pac gene of strain GS-5 consists of 3,477 bp and codes for a protein of 1,158 amino acids. One insertion of an adenine into the 3,469th, 3,470th, or 3,471st position from the start codon results in a frameshift mutation at codon 1157 with subsequent termination after 3 additional codons.
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U2 - 10.1128/iai.65.2.794-797.1997
DO - 10.1128/iai.65.2.794-797.1997
M3 - Article
C2 - 9009344
AN - SCOPUS:0031028317
SN - 0019-9567
VL - 65
SP - 794
EP - 797
JO - Infection and Immunity
JF - Infection and Immunity
IS - 2
ER -
