Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity

Takahiro Nagatake; Satoshi Fukuyama; Dong Young Kim; Kaoru Goda; Osamu Igarashi; Shintaro Sato; Tomonori Nochi; Hiroshi Sagara; Yoshifumi Yokota; Anton M. Jetten; Tsuneyasu Kaisho; Shizuo Akira; Hitomi Mimuro; Chihiro Sasakawa; Yoshinori Fukui; Kohtaro Fujihashi; Taishin Akiyama; Jun Ichiro Inoue; Josef M. Penninger; Jun Kunisawa; Hiroshi Kiyono

doi:10.1084/jem.20091436

Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity

Takahiro Nagatake, Satoshi Fukuyama, Dong Young Kim, Kaoru Goda, Osamu Igarashi, Shintaro Sato, Tomonori Nochi, Hiroshi Sagara, Yoshifumi Yokota, Anton M. Jetten, Tsuneyasu Kaisho, Shizuo Akira, Hitomi Mimuro, Chihiro Sasakawa, Yoshinori Fukui, Kohtaro Fujihashi, Taishin Akiyama, Jun Ichiro Inoue, Josef M. Penninger, Jun KunisawaHiroshi Kiyono

Department of Immunobiology and Neuroscience

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

The eye is protected by the ocular immunosurveillance system. We show that tear duct-associated lymphoid tissue (TALT) is located in the mouse lacrimal sac and shares immunological characteristics with mucosa-associated lymphoid tissues (MALTs), including the presence of M cells and immunocompetent cells for antigen uptake and subsequent generation of mucosal immune responses against ocularly encountered antigens and bacteria such as Pseudomonas aeruginosa. Initiation of TALT genesis began postnatally; it occurred even in germ-free conditions and was independent of signaling through organogenesis regulators, including inhibitor of DNA binding/differentiation 2, retinoic acid-related orphan receptor γt, lymphotoxin (LT) α1β2-LTβR, and lymphoid chemokines (CCL19, CCL21, and CXCL13). Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity.

Original language	English
Pages (from-to)	2351-2364
Number of pages	14
Journal	Journal of Experimental Medicine
Volume	206
Issue number	11
DOIs	https://doi.org/10.1084/jem.20091436
Publication status	Published - Oct 26 2009

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1084/jem.20091436

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Nagatake, T., Fukuyama, S., Kim, D. Y., Goda, K., Igarashi, O., Sato, S., Nochi, T., Sagara, H., Yokota, Y., Jetten, A. M., Kaisho, T., Akira, S., Mimuro, H., Sasakawa, C., Fukui, Y., Fujihashi, K., Akiyama, T., Inoue, J. I., Penninger, J. M., ... Kiyono, H. (2009). Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity. Journal of Experimental Medicine, 206(11), 2351-2364. https://doi.org/10.1084/jem.20091436

Nagatake, T, Fukuyama, S, Kim, DY, Goda, K, Igarashi, O, Sato, S, Nochi, T, Sagara, H, Yokota, Y, Jetten, AM, Kaisho, T, Akira, S, Mimuro, H, Sasakawa, C, Fukui, Y, Fujihashi, K, Akiyama, T, Inoue, JI, Penninger, JM, Kunisawa, J & Kiyono, H 2009, 'Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity', Journal of Experimental Medicine, vol. 206, no. 11, pp. 2351-2364. https://doi.org/10.1084/jem.20091436

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abstract = "The eye is protected by the ocular immunosurveillance system. We show that tear duct-associated lymphoid tissue (TALT) is located in the mouse lacrimal sac and shares immunological characteristics with mucosa-associated lymphoid tissues (MALTs), including the presence of M cells and immunocompetent cells for antigen uptake and subsequent generation of mucosal immune responses against ocularly encountered antigens and bacteria such as Pseudomonas aeruginosa. Initiation of TALT genesis began postnatally; it occurred even in germ-free conditions and was independent of signaling through organogenesis regulators, including inhibitor of DNA binding/differentiation 2, retinoic acid-related orphan receptor γt, lymphotoxin (LT) α1β2-LTβR, and lymphoid chemokines (CCL19, CCL21, and CXCL13). Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity.",

author = "Takahiro Nagatake and Satoshi Fukuyama and Kim, {Dong Young} and Kaoru Goda and Osamu Igarashi and Shintaro Sato and Tomonori Nochi and Hiroshi Sagara and Yoshifumi Yokota and Jetten, {Anton M.} and Tsuneyasu Kaisho and Shizuo Akira and Hitomi Mimuro and Chihiro Sasakawa and Yoshinori Fukui and Kohtaro Fujihashi and Taishin Akiyama and Inoue, {Jun Ichiro} and Penninger, {Josef M.} and Jun Kunisawa and Hiroshi Kiyono",

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T1 - Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity

AU - Nagatake, Takahiro

AU - Fukuyama, Satoshi

AU - Kim, Dong Young

AU - Goda, Kaoru

AU - Igarashi, Osamu

AU - Sato, Shintaro

AU - Nochi, Tomonori

AU - Sagara, Hiroshi

AU - Yokota, Yoshifumi

AU - Jetten, Anton M.

AU - Kaisho, Tsuneyasu

AU - Akira, Shizuo

AU - Mimuro, Hitomi

AU - Sasakawa, Chihiro

AU - Fukui, Yoshinori

AU - Fujihashi, Kohtaro

AU - Akiyama, Taishin

AU - Inoue, Jun Ichiro

AU - Penninger, Josef M.

AU - Kunisawa, Jun

AU - Kiyono, Hiroshi

PY - 2009/10/26

Y1 - 2009/10/26

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AB - The eye is protected by the ocular immunosurveillance system. We show that tear duct-associated lymphoid tissue (TALT) is located in the mouse lacrimal sac and shares immunological characteristics with mucosa-associated lymphoid tissues (MALTs), including the presence of M cells and immunocompetent cells for antigen uptake and subsequent generation of mucosal immune responses against ocularly encountered antigens and bacteria such as Pseudomonas aeruginosa. Initiation of TALT genesis began postnatally; it occurred even in germ-free conditions and was independent of signaling through organogenesis regulators, including inhibitor of DNA binding/differentiation 2, retinoic acid-related orphan receptor γt, lymphotoxin (LT) α1β2-LTβR, and lymphoid chemokines (CCL19, CCL21, and CXCL13). Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity.

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Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity

Abstract

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