Hypoxia-inducible adrenomedullin in colorectal cancer

Mamoru Uemura, Hirofumi Yamamoto, Ichiro Takemasa, Koshi Mimori, Tsunekazu Mizushima, Masataka Ikeda, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Background: Recently, we determined several potential prognostic factors in vivo using hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC). Among them, expression of adrenomedullin (ADM) was an interesting target because it is highly induced by hypoxia. Patients and Methods: To evaluate the prognostic impact of the expression of ADM, samples from a total of 373 CRC patients were analyzed by microarray (n=222), and quantitative reverse-transcriptase polymerase chain reaction (n=151). Results: ADM was a novel independent prognostic factor for CRC (p=0.027). ADM expression correlated with hypoxia-inducible factor-1 A (p<0.0001) and vascular endothelial growth factor (p<0.0001) in vivo. Conclusion: ADM expression is a useful marker for predicting high risk of relapse and cancer-related death in patients who have undergone curative resection for CRC.

Original languageEnglish
Pages (from-to)507-514
Number of pages8
JournalAnticancer research
Issue number2
Publication statusPublished - Feb 2011

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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