TY - JOUR
T1 - Hypoxemia due to pulmonary tumor microembolisms from a hepatocellular carcinoma
T2 - a case report
AU - Yamashita, Nobuyuki
AU - Tanimoto, Hironori
AU - Yamamoto, Hidetaka
AU - Nishiura, Saburo
AU - Nomura, Hideyuki
PY - 2015/6/1
Y1 - 2015/6/1
N2 - We report a case of pulmonary tumor embolism due to hepatocellular carcinoma (HCC). A woman in her 60s was treated with sorafenib 800 mg daily for HCC with lymph node metastasis. Approximately 50 days after taking sorafenib, she experienced dyspnea and was admitted to the hospital on account of hypoxia. Although her oxygen saturation levels deteriorated, we could find no obvious cause for the hypoxia; despite artificial respiration and oxygenation, she died of respiratory failure on the fourth day of admission. Tissue samples revealed that the HCC cells had infiltrated her lung arterioles; therefore, we concluded that multiple tumor microembolisms from the HCC to the lungs had caused death via respiratory failure. Cases of hypoxia caused by multiple invisible embolisms from HCCs are rarely reported. We believe that infiltration into the lymphatic system may have been related to the development of pulmonary tumor microembolisms.
AB - We report a case of pulmonary tumor embolism due to hepatocellular carcinoma (HCC). A woman in her 60s was treated with sorafenib 800 mg daily for HCC with lymph node metastasis. Approximately 50 days after taking sorafenib, she experienced dyspnea and was admitted to the hospital on account of hypoxia. Although her oxygen saturation levels deteriorated, we could find no obvious cause for the hypoxia; despite artificial respiration and oxygenation, she died of respiratory failure on the fourth day of admission. Tissue samples revealed that the HCC cells had infiltrated her lung arterioles; therefore, we concluded that multiple tumor microembolisms from the HCC to the lungs had caused death via respiratory failure. Cases of hypoxia caused by multiple invisible embolisms from HCCs are rarely reported. We believe that infiltration into the lymphatic system may have been related to the development of pulmonary tumor microembolisms.
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U2 - 10.11405/nisshoshi.112.1060
DO - 10.11405/nisshoshi.112.1060
M3 - Article
C2 - 26050730
SN - 0446-6586
VL - 112
SP - 1060
EP - 1066
JO - Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
JF - Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
IS - 6
ER -