Hypothalamic regulation of sodium-potassium pump activity in skeletal muscle

Hironobu Yoshimatsu; Yutaka Oomura; Toshihiko Katafuchi; Norio Akaike

doi:10.1016/0006-8993(86)91214-X

Hypothalamic regulation of sodium-potassium pump activity in skeletal muscle

Hironobu Yoshimatsu, Yutaka Oomura, Toshihiko Katafuchi, Norio Akaike

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Abstract

The suppression of active Na⁺-K⁺ transport in rat skeletal muscle during hypokalemia was counteracted by bilateral electrolytic lesion of the ventromedial hypothalamic nucleus. This reversal effect was unaffected even after pancreatectomy or adrenalectomy. The anomalous electrolyte content in hypokalemic rat muscles was aggravated by lesion of the dorsomedial hypothalamic nucleus and of the anterior hypothalamus. The results indicate that the hypothalamus is involve in the regulation of the Na⁺-K⁺ transport system in skeletal muscle during hypokalemia.

Original language	English
Pages (from-to)	17-22
Number of pages	6
Journal	Brain Research
Volume	384
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(86)91214-X
Publication status	Published - Oct 1 1986

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(86)91214-X

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AU - Katafuchi, Toshihiko

AU - Akaike, Norio

PY - 1986/10/1

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AB - The suppression of active Na+-K+ transport in rat skeletal muscle during hypokalemia was counteracted by bilateral electrolytic lesion of the ventromedial hypothalamic nucleus. This reversal effect was unaffected even after pancreatectomy or adrenalectomy. The anomalous electrolyte content in hypokalemic rat muscles was aggravated by lesion of the dorsomedial hypothalamic nucleus and of the anterior hypothalamus. The results indicate that the hypothalamus is involve in the regulation of the Na+-K+ transport system in skeletal muscle during hypokalemia.

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Hypothalamic regulation of sodium-potassium pump activity in skeletal muscle

Abstract

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