TY - JOUR
T1 - Hypothalamic microdialysis of mazindol causes anorexia with increase in synaptic serotonin in rats
AU - Shimizu, Nobuaki
AU - Take, Sachiko
AU - Hori, Tetsuro
AU - Oomura, Yutaka
PY - 1991/1
Y1 - 1991/1
N2 - Brain microdialysis was used to determine if lateral hypothalamic serotonin (5-HT) is involved in the mazindol-induced anorexia in rats. Direct application of mazindol through a microdialysis membrane both significantly increased the 5-HT levels in the lateral hypothalamus and suppressed food intake by fasted rats. The increase in 5-HT concentration was dose related and the concentration of mazindol for half-maximal response was 4.6 μM. Pretreatment with methysergide, a potent 5-HT receptor-blocking agent, significantly antagonized the mazindol-induced anorexia. These results suggest that the anorectic action of mazindol might be mediated, at least in part, through serotonergic mechanisms in the hypothalamus.
AB - Brain microdialysis was used to determine if lateral hypothalamic serotonin (5-HT) is involved in the mazindol-induced anorexia in rats. Direct application of mazindol through a microdialysis membrane both significantly increased the 5-HT levels in the lateral hypothalamus and suppressed food intake by fasted rats. The increase in 5-HT concentration was dose related and the concentration of mazindol for half-maximal response was 4.6 μM. Pretreatment with methysergide, a potent 5-HT receptor-blocking agent, significantly antagonized the mazindol-induced anorexia. These results suggest that the anorectic action of mazindol might be mediated, at least in part, through serotonergic mechanisms in the hypothalamus.
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U2 - 10.1016/0031-9384(91)90243-H
DO - 10.1016/0031-9384(91)90243-H
M3 - Article
C2 - 2017466
AN - SCOPUS:0026086174
SN - 0031-9384
VL - 49
SP - 131
EP - 134
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 1
ER -