TY - JOUR
T1 - Hypoglycemic activity of methanolic leaf extract of Blumea lacera in Swiss-albino mice
AU - Hasan, Md Nazmul
AU - Rahman, Mohammad Habibur
AU - Guo, Renkai
AU - Hirashima, Akinori
N1 - Funding Information:
*Corresponding author: Dr. Akinori Hirashima, Laboratory of Pesticide Chemistry, Division of Molecular Biosciences, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan. Tel/Fax: +81-92-6?2-2856. E-mail: ahirasim@agr.kyushu-u.ac.jp Foundation Project: Supported by University Grant Commission, Bangladesh (Grant No. 6(75)/Bio(31)/2009-2010/7700, Date–11/09/2011).
Publisher Copyright:
© 2015 by the Asian Pacific Journal of Tropical Disease.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Objective: To estimate the hypoglycemic activity of Blumea lacera (B. lacera) leaf methanol extract. Methods: A study was undertaken for preliminary exploration of hypoglycemic activity via oral glucose tolerance test. B. lacera leaves were dried under shaded sunlight, milled and then macerated in methanol. Glibenclamide was used as reference drug, and 50-400 mg/kg leaf extract was administered orally to four test groups. Results: Treatment of leaf extract on glucose loaded hypoglycemic mice lead to significant (P<0.0001) reduction of the blood glucose levels in a dose dependent manner. Conclusions: The result suggests that methanolic leaf extract of B. lacera possesses anti-diabetic properties, and its use as ethnomedicine for treatment of diabetes.
AB - Objective: To estimate the hypoglycemic activity of Blumea lacera (B. lacera) leaf methanol extract. Methods: A study was undertaken for preliminary exploration of hypoglycemic activity via oral glucose tolerance test. B. lacera leaves were dried under shaded sunlight, milled and then macerated in methanol. Glibenclamide was used as reference drug, and 50-400 mg/kg leaf extract was administered orally to four test groups. Results: Treatment of leaf extract on glucose loaded hypoglycemic mice lead to significant (P<0.0001) reduction of the blood glucose levels in a dose dependent manner. Conclusions: The result suggests that methanolic leaf extract of B. lacera possesses anti-diabetic properties, and its use as ethnomedicine for treatment of diabetes.
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U2 - 10.1016/S2222-1808(14)60652-6
DO - 10.1016/S2222-1808(14)60652-6
M3 - Article
AN - SCOPUS:84921502460
SN - 2222-1808
VL - 5
SP - 195
EP - 198
JO - Asian Pacific Journal of Tropical Disease
JF - Asian Pacific Journal of Tropical Disease
IS - 3
ER -
