Hydroxylation mediates chromatin demethylation

Yu Ichi Tsukada

    Research output: Contribution to journalReview articlepeer-review

    22 Citations (Scopus)

    Abstract

    Methylation of DNA and histones in chromatin has been implicated in numerous biological processes. For many years, methylation has been recognized as static and stable modification, as compared with other covalent modifications of chromatin. Recently, however, several mechanisms have been demonstrated to be involved in demethylation of chromatin, suggesting that chromatin methylation is more dynamically regulated. One chemical reaction that mediates demethylation of both DNA and histones is hydroxylation, catalysed by Fe(II) and α-ketoglutarate (KG)-dependent hydroxylase/dioxygenase. Given that methylation of chromatin is an important epigenetic mark involved in fundamental biological processes such as cell fate determination, understanding how chromatin methylation is dynamically regulated has implications for human diseases and regenerative medicine.

    Original languageEnglish
    Pages (from-to)229-246
    Number of pages18
    JournalJournal of biochemistry
    Volume151
    Issue number3
    DOIs
    Publication statusPublished - Mar 2012

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Molecular Biology

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