Hydroxyl radical-suppressing mechanism and efficiency of melanin-mimetic nanoparticles

Koichiro Hayashi; Atsuto Tokuda; Wataru Sakamoto

doi:10.3390/ijms19082309

Hydroxyl radical-suppressing mechanism and efficiency of melanin-mimetic nanoparticles

Koichiro Hayashi, Atsuto Tokuda, Wataru Sakamoto

Oral Rehabilitation

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Abstract

Harnessing melanins to scavenge free radicals in vivo may yield treatment methods for inflammatory disorders. Furthermore, elucidation of the mechanism underlying melanin-mediated suppression of free radicals, which is yet unclear, is warranted. Herein, we chemically synthesized melanin-mimetic nanoparticles (MeNPs) and investigated the mechanism underlying their use. MeNPs efficiently suppressed hydroxyl radicals by converting some MeNP hydroxyl groups to ketone groups. Furthermore, they suppressed hydroxyl radicals produced by lipopolysaccharide-treated Kupffer cells involved in hepatic cirrhosis pathogenesis, without causing significant cytotoxicity. The present results indicate the suitability of MeNPs to treat hepatic cirrhosis; however, further in vivo studies are warranted to determine their treatment efficacy.

Original language	English
Article number	2309
Journal	International journal of molecular sciences
Volume	19
Issue number	8
DOIs	https://doi.org/10.3390/ijms19082309
Publication status	Published - Aug 7 2018

All Science Journal Classification (ASJC) codes

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms19082309

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title = "Hydroxyl radical-suppressing mechanism and efficiency of melanin-mimetic nanoparticles",

abstract = "Harnessing melanins to scavenge free radicals in vivo may yield treatment methods for inflammatory disorders. Furthermore, elucidation of the mechanism underlying melanin-mediated suppression of free radicals, which is yet unclear, is warranted. Herein, we chemically synthesized melanin-mimetic nanoparticles (MeNPs) and investigated the mechanism underlying their use. MeNPs efficiently suppressed hydroxyl radicals by converting some MeNP hydroxyl groups to ketone groups. Furthermore, they suppressed hydroxyl radicals produced by lipopolysaccharide-treated Kupffer cells involved in hepatic cirrhosis pathogenesis, without causing significant cytotoxicity. The present results indicate the suitability of MeNPs to treat hepatic cirrhosis; however, further in vivo studies are warranted to determine their treatment efficacy.",

author = "Koichiro Hayashi and Atsuto Tokuda and Wataru Sakamoto",

note = "Funding Information: Acknowledgments: This work was supported by JSPS KAKENHI (JP15K14146 and JP17H03403). Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",

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N2 - Harnessing melanins to scavenge free radicals in vivo may yield treatment methods for inflammatory disorders. Furthermore, elucidation of the mechanism underlying melanin-mediated suppression of free radicals, which is yet unclear, is warranted. Herein, we chemically synthesized melanin-mimetic nanoparticles (MeNPs) and investigated the mechanism underlying their use. MeNPs efficiently suppressed hydroxyl radicals by converting some MeNP hydroxyl groups to ketone groups. Furthermore, they suppressed hydroxyl radicals produced by lipopolysaccharide-treated Kupffer cells involved in hepatic cirrhosis pathogenesis, without causing significant cytotoxicity. The present results indicate the suitability of MeNPs to treat hepatic cirrhosis; however, further in vivo studies are warranted to determine their treatment efficacy.

AB - Harnessing melanins to scavenge free radicals in vivo may yield treatment methods for inflammatory disorders. Furthermore, elucidation of the mechanism underlying melanin-mediated suppression of free radicals, which is yet unclear, is warranted. Herein, we chemically synthesized melanin-mimetic nanoparticles (MeNPs) and investigated the mechanism underlying their use. MeNPs efficiently suppressed hydroxyl radicals by converting some MeNP hydroxyl groups to ketone groups. Furthermore, they suppressed hydroxyl radicals produced by lipopolysaccharide-treated Kupffer cells involved in hepatic cirrhosis pathogenesis, without causing significant cytotoxicity. The present results indicate the suitability of MeNPs to treat hepatic cirrhosis; however, further in vivo studies are warranted to determine their treatment efficacy.

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Hydroxyl radical-suppressing mechanism and efficiency of melanin-mimetic nanoparticles

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