TY - GEN
T1 - Hydroxyapatite hybridized with metal oxides for biomedical applications
AU - Osaka, Akiyoshi
AU - Fujii, Eiji
AU - Kawabata, Koji
AU - Yoshimatsu, Hideyuki
AU - Hayakawa, Satoshi
AU - Tsuru, Kanji
AU - Bonhomme, Christian
AU - Babonneau, Florence
PY - 2006/12/1
Y1 - 2006/12/1
N2 - Zn-substituted apatites with homogeneous Zn distribution in the particles (ZnΦHAp) and those with graded distribution (Zn/HAp) were prepared via a conventional wet chemical synthesis and soaking the Zn-free apatite particles in zinc nitrate solutions: X-ray photoelectron spectra of the apatites confirmed such Zn distribution. Physical and chemical properties such as particle size, specific surface area, or zeta-potential and were correlated to adsorption of β2-microglobulin (β2-MG) and bovine serum albumin (BSA). Adsorption of β2-MG on both apatites increased with the Zn content, whereas more β2-MG was adsorbed on Zn/HAp than on ZnΦHAp. The amount of BSA adsorbed on ZnΦHAp reached a maximum at about 1.5%, while it remained constant for Zn/HAp. From the results, it was suggested that Zn-substituted sites had better affinity against β2-MG and favored β2-MG adsorption. Surface charge on the particles was one of the factors to explain the suppressed adsorption of BSA by both apatites.
AB - Zn-substituted apatites with homogeneous Zn distribution in the particles (ZnΦHAp) and those with graded distribution (Zn/HAp) were prepared via a conventional wet chemical synthesis and soaking the Zn-free apatite particles in zinc nitrate solutions: X-ray photoelectron spectra of the apatites confirmed such Zn distribution. Physical and chemical properties such as particle size, specific surface area, or zeta-potential and were correlated to adsorption of β2-microglobulin (β2-MG) and bovine serum albumin (BSA). Adsorption of β2-MG on both apatites increased with the Zn content, whereas more β2-MG was adsorbed on Zn/HAp than on ZnΦHAp. The amount of BSA adsorbed on ZnΦHAp reached a maximum at about 1.5%, while it remained constant for Zn/HAp. From the results, it was suggested that Zn-substituted sites had better affinity against β2-MG and favored β2-MG adsorption. Surface charge on the particles was one of the factors to explain the suppressed adsorption of BSA by both apatites.
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M3 - Conference contribution
AN - SCOPUS:33846009440
SN - 0470080566
SN - 9780470080566
T3 - Ceramic Engineering and Science Proceedings
SP - 39
EP - 47
BT - Advances in Bioceramics and Biocomposites II - A Collection of Papers Presented at the 30th International Conference on Advanced Ceramics and Composites
T2 - Advances in Bioceramics and Biocomposites II - 30th International Conference on Advanced Ceramics and Composites
Y2 - 22 January 2006 through 27 January 2006
ER -