TY - JOUR
T1 - Human T lymphotropic virus type 1 infection influences hepatitis C virus clearance
AU - Kishihara, Y.
AU - Furusyo, N.
AU - Kashiwagi, K.
AU - Mitsutake, A.
AU - Kashiwagi, S.
AU - Hayashi, J.
N1 - Funding Information:
Written informed consent was obtained from all patients in this survey. The study was approved by the Kyushu University Hospital ethics committee and was conducted in accordance with the human experimentation guidelines of the US Department of Health and Human Services. Financial support: Fukuoka Cancer Society (grant in aid).
PY - 2001/11/1
Y1 - 2001/11/1
N2 - To explore the effect of human T lymphotropic virus type 1 (HTLV-1) infection on hepatitis C virus (HCV) infection, a survey for these viral infections was conducted that involved 2280 residents in an area in which HTLV-1 and HCV are endemic. The response of patients with HCV and HTLV-1 to interferon (IFN)-α treatment was also assessed. Antibody to HCV was detected in 13.8% of the residents tested, and antibody to HTLV-1 was detected in 15.4%. The prevalence of HCV RNA was significantly higher among residents who had antibodies to both HCV and HTLV-1 than in those who had antibodies to HCV only (P < .05). Sustained elimination of HCV RNA by IFN was significantly more frequent among patients with HCV alone than among those with HCV and HTLV-1. By logistic regression analysis, HTLV-1 infection was associated with nonresponse to IFN treatment. Thus, HTLV-1 infection affects the clearance, both natural and in association with IFN treatment, of HCV.
AB - To explore the effect of human T lymphotropic virus type 1 (HTLV-1) infection on hepatitis C virus (HCV) infection, a survey for these viral infections was conducted that involved 2280 residents in an area in which HTLV-1 and HCV are endemic. The response of patients with HCV and HTLV-1 to interferon (IFN)-α treatment was also assessed. Antibody to HCV was detected in 13.8% of the residents tested, and antibody to HTLV-1 was detected in 15.4%. The prevalence of HCV RNA was significantly higher among residents who had antibodies to both HCV and HTLV-1 than in those who had antibodies to HCV only (P < .05). Sustained elimination of HCV RNA by IFN was significantly more frequent among patients with HCV alone than among those with HCV and HTLV-1. By logistic regression analysis, HTLV-1 infection was associated with nonresponse to IFN treatment. Thus, HTLV-1 infection affects the clearance, both natural and in association with IFN treatment, of HCV.
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U2 - 10.1086/323890
DO - 10.1086/323890
M3 - Article
C2 - 11598833
AN - SCOPUS:0035500952
SN - 0022-1899
VL - 184
SP - 1114
EP - 1119
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 9
ER -
