Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation

T. Juji; Y. Watanabe; Yoshihide Ishikawa; K. Fujiwara; H. Tonami; H. Tanaka; M. Satake; T. Akaza; K. Tadokoro; Y. Kodera; T. Sasazuki; Y. Morishima; F. Takaku

doi:10.1034/j.1399-0039.1999.540303.x

Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation

T. Juji, Y. Watanabe, Yoshihide Ishikawa, K. Fujiwara, H. Tonami, H. Tanaka, M. Satake, T. Akaza, K. Tadokoro, Y. Kodera, T. Sasazuki, Y. Morishima, F. Takaku

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Matching of human platelet alloantigen (HPA) systems 2-6 was retrospectively investigated in 715 unrelated bone marrow transplantations. Of the five HPA systems studied, HPA-5 mismatching was found to have a significant effect on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The effect of the HPA-5 mismatch was most significant in the recipient group possessing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotype among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching decreases the recipient's survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD.

Original language	English
Pages (from-to)	229-234
Number of pages	6
Journal	Tissue antigens
Volume	54
Issue number	3
DOIs	https://doi.org/10.1034/j.1399-0039.1999.540303.x
Publication status	Published - 1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics
Biochemistry
Immunology and Allergy
Immunology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1034/j.1399-0039.1999.540303.x

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Juji, T., Watanabe, Y., Ishikawa, Y., Fujiwara, K., Tonami, H., Tanaka, H., Satake, M., Akaza, T., Tadokoro, K., Kodera, Y., Sasazuki, T., Morishima, Y., & Takaku, F. (1999). Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation. Tissue antigens, 54(3), 229-234. https://doi.org/10.1034/j.1399-0039.1999.540303.x

Juji, T, Watanabe, Y, Ishikawa, Y, Fujiwara, K, Tonami, H, Tanaka, H, Satake, M, Akaza, T, Tadokoro, K, Kodera, Y, Sasazuki, T, Morishima, Y & Takaku, F 1999, 'Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation', Tissue antigens, vol. 54, no. 3, pp. 229-234. https://doi.org/10.1034/j.1399-0039.1999.540303.x

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abstract = "Matching of human platelet alloantigen (HPA) systems 2-6 was retrospectively investigated in 715 unrelated bone marrow transplantations. Of the five HPA systems studied, HPA-5 mismatching was found to have a significant effect on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The effect of the HPA-5 mismatch was most significant in the recipient group possessing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotype among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching decreases the recipient's survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD.",

author = "T. Juji and Y. Watanabe and Yoshihide Ishikawa and K. Fujiwara and H. Tonami and H. Tanaka and M. Satake and T. Akaza and K. Tadokoro and Y. Kodera and T. Sasazuki and Y. Morishima and F. Takaku",

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AU - Juji, T.

AU - Watanabe, Y.

AU - Ishikawa, Yoshihide

AU - Fujiwara, K.

AU - Tonami, H.

AU - Tanaka, H.

AU - Satake, M.

AU - Akaza, T.

AU - Tadokoro, K.

AU - Kodera, Y.

AU - Sasazuki, T.

AU - Morishima, Y.

AU - Takaku, F.

PY - 1999

Y1 - 1999

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AB - Matching of human platelet alloantigen (HPA) systems 2-6 was retrospectively investigated in 715 unrelated bone marrow transplantations. Of the five HPA systems studied, HPA-5 mismatching was found to have a significant effect on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The effect of the HPA-5 mismatch was most significant in the recipient group possessing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotype among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching decreases the recipient's survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD.

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Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation

Abstract

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