Human obesity and point mutations of leptin and leptin receptor

H. Nishimura, Y. Ogawa, K. Nakao

Research output: Contribution to journalReview articlepeer-review


Obesity-related genes were isolated and identified in these several years. Development of transgenic mice has clarified the molecular mechanisms of obesity. There have been reported point mutations of the genes correspond to leptin(ob-gene) and leptin receptor(db-gene). Thereby leptin is considered to be one of the most important regulators of energy metabolism also in human.

Original languageEnglish
Pages (from-to)571-577
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number3
Publication statusPublished - Mar 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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