Human herpesvirus 6 induces IL-8 gene expression in human hepatoma cell line, Hep G2

Reiko Inagi, Ratigorn Guntapong, Masayuki Nakao, Yoshizumi Ishino, Kazunobu Kawanishi, Yuji Isegawa, Koichi Yamanishi

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42 Citations (Scopus)


The infectivity of human herpesvirus 6 (HHV-6) in a human hepatoma cell line, Hep G2 cells, and the effect of HHV-6 on production of inflammatory cytokines in these cells were examined to analyze pathogenesis of HHV-6 in the liver. We demonstrated that Hep G2 cells were susceptible to infection with HHV-6, and produced infectious virus. Moreover, infection of Hep G2 cells by HHV-6 induced the expression of IL-8 mRNA, but not IL-1β. The effect on induction of IL-8 gene expression was observed only in Hep G2 cells infected with infectious virus, whereas both heat-inactivated HHV-6 and UV-irradiated HHV-6 did not change the IL-8 mRNA level in these cells. These data suggest that HHV-6 may induce the cytokine-mediated inflammatory response by infecting liver cells, which could result in liver dysfunction in vivo.

Original languageEnglish
Pages (from-to)34-40
Number of pages7
JournalJournal of Medical Virology
Issue number1
Publication statusPublished - May 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Virology


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